Visual-Motor Integration Deficits in 3q29 Deletion Syndrome.
3q29 deletion syndrome (3q29del) is associated with neuropsychiatric and neurodevelopmental phenotypes. We previously reported that graphomotor weakness is present in up to 78% of individuals with 3q29del. We have now explored nuances of the graphomotor phenotype and its association with other comor...
| Publicado en: | Journal of Autism & Developmental Disorders Vol. 54; no. 8; pp. 3142 - 3155 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Aug2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=178836275&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 178836275 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01623257 AUT jtl: Journal of Autism & Developmental Disorders issn: 01623257 maglogo: N pubinfo: dt: Aug2024 vid: 54 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 178836275 164458490 178836275 178836275 10.1007/s10803-023-06034-2 178836275 ppf: 3142 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Visual-Motor Integration Deficits in 3q29 Deletion Syndrome. aug: au: Pollak, Rebecca M. Burrell, T. Lindsey Cubells, Joseph F. Klaiman, Cheryl Murphy, Melissa M. Saulnier, Celine A. Walker, Elaine F. White, Stormi Pulver Mulle, Jennifer G. affil: https://ror.org/05vt9qd57 Center for Advanced Biotechnology and Medicine and Department of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, 679 Hoes Lane West, 08854, Piscataway, NJ, USA sug: subj: Mutation Phenotype Visual Perception Physiology Motor Skills Human Female Male Cognition Executive Function Adaptation, Psychological Academic Performance Early Intervention Child, Preschool Child Adolescence Adult Funding Source Child, Preschool: 2-5 years Child: 6-12 years Adolescent: 13-18 years Adult: 19-44 years Female Male ab: 3q29 deletion syndrome (3q29del) is associated with neuropsychiatric and neurodevelopmental phenotypes. We previously reported that graphomotor weakness is present in up to 78% of individuals with 3q29del. We have now explored nuances of the graphomotor phenotype and its association with other comorbidities in this population. Participants were recruited from the online 3q29 registry (3q29deletion.org) for two days of deep phenotyping. 32 individuals with 3q29del (62.5% male) were evaluated with the Beery-Buktenica Developmental Test of Visual-Motor Integration (VMI) to assess visual-motor integration. Participants were also evaluated with measures of cognitive ability, executive function, adaptive behavior, and school function. Males with 3q29del performed significantly worse than females on the VMI and Motor Coordination subtest. VMI performance was significantly associated with ADHD diagnosis and cognitive ability. Compared to published data from individuals with 22q11.2 deletion syndrome, individuals with 3q29del showed significantly more impairment. The 3q29 deletion is associated with substantial deficits in visual-motor integration, Visual Perception, and Motor Coordination. Our data suggests that 3q29del may qualify as a nonverbal learning disability. Future studies should assess whether individuals with 3q29del would benefit from early interventions, including occupational therapy. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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