Lessons learned in application driven imaging agent design for image-guided surgery.
To meet the growing demand for intraoperative molecular imaging, the development of compatible imaging agents plays a crucial role. Given the unique requirements of surgical applications compared to diagnostics and therapy, maximizing translational potential necessitates distinctive imaging agent de...
| Publicado en: | European Journal of Nuclear Medicine & Molecular Imaging Vol. 51; no. 10; pp. 3040 - 3055 |
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| Autores principales: | , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Aug2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=178837435&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 178837435 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16197070 NPC jtl: European Journal of Nuclear Medicine & Molecular Imaging issn: 16197070 maglogo: N pubinfo: dt: Aug2024 vid: 51 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 178837435 177981300 10.1007/s00259-024-06791-x 178837435 ppf: 3040 ppct: 15 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Lessons learned in application driven imaging agent design for image-guided surgery. aug: au: Buckle, Tessa Rietbergen, Daphne D. D. de Wit -van der Veen, Linda Schottelius, Margret affil: https://ror.org/05xvt9f17 Interventional Molecular Imaging Laboratory, Leiden University Medical Center, Leiden, The Netherlands sug: ab: To meet the growing demand for intraoperative molecular imaging, the development of compatible imaging agents plays a crucial role. Given the unique requirements of surgical applications compared to diagnostics and therapy, maximizing translational potential necessitates distinctive imaging agent designs. For effective surgical guidance, exogenous signatures are essential and are achievable through a diverse range of imaging labels such as (radio)isotopes, fluorescent dyes, or combinations thereof. To achieve optimal in vivo utility a balanced molecular design of the tracer as a whole is required, which ensures a harmonious effect of the imaging label with the affinity and specificity (e.g., pharmacokinetics) of a pharmacophore/targeting moiety. This review outlines common design strategies and the effects of refinements in the molecular imaging agent design on the agent's pharmacological profile. This includes the optimization of affinity, pharmacokinetics (including serum binding and target mediated background), biological clearance route, the achievable signal intensity, and the effect of dosing hereon. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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