Carcinoma of the tympanic membrane: A case report of an interesting and unusual lesion.
Primary tympanic membrane squamous cell carcinomas are exceedingly rare. We present a case of tympanic membrane squamous cell carcinoma in a 54-year-old female that infiltrated the full thickness of the temporal bone leading to intracranial extension and dural involvement. The diagnosis was suspecte...
| Published in: | Canadian Journal of Pathology Vol. 16; no. 3; pp. 29 - 35 |
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| Main Authors: | , , , |
| Format: | case study diagnostic images pictorial Journal Article |
| Published: |
Canadian Association of Pathologists
Aug2024
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=178891138&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 178891138 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1918915X B17Q jtl: Canadian Journal of Pathology issn: 1918915X maglogo: N pubinfo: dt: Aug2024 vid: 16 iid: 3 pid: 62888 pub: Canadian Association of Pathologists place: Kingston, Ontario artinfo: ui: 178891138 178891138 178891138 178891138 ppf: 29 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Carcinoma of the tympanic membrane: A case report of an interesting and unusual lesion. aug: au: Flynn, Jayne Ndikumana, Robyn Ken Kao Kirby, Simon affil: Memorial University of Newfoundland, St. John’s, NL, Canada. sug: subj: Ear Neoplasms Diagnosis Squamous Cell Carcinoma of Head and Neck Diagnosis Tympanic Membrane Pathology Ear Neoplasms Surgery Squamous Cell Carcinoma of Head and Neck Surgery Tympanic Membrane Surgery Female Middle Age Rare Diseases Temporal Bone Pathology Biopsy Staining and Labeling Microscopy Immunohistochemistry Tumor Markers, Biological Fibrosis Etiology Tomography, X-Ray Computed Magnetic Resonance Imaging Neoplasm Staging Dissection Temporal Bone Surgery Temporomandibular Joint Surgery Surgical Flaps Middle Aged: 45-64 years Female ab: Primary tympanic membrane squamous cell carcinomas are exceedingly rare. We present a case of tympanic membrane squamous cell carcinoma in a 54-year-old female that infiltrated the full thickness of the temporal bone leading to intracranial extension and dural involvement. The diagnosis was suspected on initial histology and supported by microscopy and ancillary immunohistochemistry including diffusely positive nuclear PLAG1 positivity. Diagnosis of tympanic membrane squamous cell carcinoma is extremely important as surgical excision is the mainstay of treatment given the unknown malignant potential. Histology, microscopy, and IHC provide definitive diagnosis while magnetic resonance imaging can determine extent of spread. Les cas de carcinome épidermoïde primitif de la membrane tympanique sont extrêmement rares. Nous présentons un cas, chez une femme de 54 ans, de carcinome épidermoïde de la membrane tympanique qui a infiltré toute l’épaisseur de l’os temporal, entraînant une extension intracrânienne et une atteinte durale. Les caractéristiques histologiques initiales ont amené à soupçonner ce diagnostic, qui a été confirmé par examen microscopique et analyse immunohistochimique connexe, y compris par une expression nucléaire positive et diffuse de la protéine PLAG1. Poser le diagnostic de carcinome épidermoïde de la membrane tympanique est extrêmement important, car l’excision chirurgicale est la pierre angulaire du traitement, étant donné le potentiel malin inconnu. Les analyses histologique, microscopique et par IHC ont permis de poser un diagnostic définitif, tandis que l’imagerie par résonance magnétique a permis de déterminer l’étendue de la propagation. pubtype: Academic Journal doctype: case study diagnostic images pictorial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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