A Systematic Review on the Risk Factors of Steroid-sensitive Nephrotic Syndrome Relapse in the Pediatric Population.

Background: Identifying affecting and predictive factors of steroid-sensitive nephrotic syndrome's (SSNS's) outcome may greatly benefit the proper management of SSNS patients.. Objectives: The current systematic review comprehensively reviews all available evidence on the risk factors of SSNS relaps...

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Publicado en:Journal of Pediatrics Review Vol. 12; no. 2; pp. 153 - 171
Autores principales: Yousefifard, Mahmoud, Ahmadzadeh, Koohyar, Neishaboori, Arian Madani, Rafiei Alavi, Seyedeh Niloufar, Rafiei Alavi, Seyedeh Romina, Ahmadzadeh, Hooman, Toloui, Amirmohammad, Gubari, Mohammed I. M., Jones, Michael E., Ataei, Nematollah, Fazel, Mojtaba, Hosseini, Mostafa
Formato: research systematic review tables/charts Journal Article
Publicado: Mazandaran University of Medical Sciences Apr2024
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Apr2024
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      pub: Mazandaran University of Medical Sciences
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        10.32598/jpr.12.2.1190.1
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        atl: A Systematic Review on the Risk Factors of Steroid-sensitive Nephrotic Syndrome Relapse in the Pediatric Population.
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          Yousefifard, Mahmoud
          Ahmadzadeh, Koohyar
          Neishaboori, Arian Madani
          Rafiei Alavi, Seyedeh Niloufar
          Rafiei Alavi, Seyedeh Romina
          Ahmadzadeh, Hooman
          Toloui, Amirmohammad
          Gubari, Mohammed I. M.
          Jones, Michael E.
          Ataei, Nematollah
          Fazel, Mojtaba
          Hosseini, Mostafa
        affil: Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran
      sug:
        subj:
          Nephrotic Syndrome Drug Therapy
          Nephrotic Syndrome Drug Therapy
          Steroids Therapeutic Use
          Recurrence Risk Factors
          Risk Assessment
          Human
          Child
          Adolescence
          Systematic Review
          Medline
          Embase
          Treatment Outcomes
          Hematuria
          Hypertension
          Funding Source
          Male
          Female
          Time
          Age Factors
          Sex Factors
          Creatinine Blood
          Blood Proteins Analysis
          Child: 6-12 years
          Adolescent: 13-18 years
          Male
          Female
      ab: Background: Identifying affecting and predictive factors of steroid-sensitive nephrotic syndrome's (SSNS's) outcome may greatly benefit the proper management of SSNS patients.. Objectives: The current systematic review comprehensively reviews all available evidence on the risk factors of SSNS relapse in children and adolescents.. Methods: An extensive search was conducted on the electronic databases of Medline, Embase, Web of Science, and Scopus until February 18, 2024. Studies investigating the risk factors of relapse were included in this systematic review.. Results: A total of 11 articles were included. Age, gender, and laboratory variables, such as serum creatinine and serum protein are not risk factors for relapse in these studies. Possible associations were reported for risk factors, such as the number of relapses and response time. Overall, the studies reported conflicting results on the value of relapse risk factors.. Conclusions: Although factors, such as hematuria, hypertension, time from treatment to response, and number of relapses have been proposed as possible risk factors for relapse, no conclusion can be reached due to the heterogeneity of studies. Future studies should have more conforming designs to make comparisons more reliable.
      pubtype: Academic Journal
      doctype:
        research
        systematic review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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