Histological investigation in aging male and female gerbil prostates after prenatal exposure to pequi (Caryocar brasiliense Cambess) oil and 17α-ethinylestradiol.
The female prostate, also known as Skene's gland, is present in both humans and rodents. Prenatal exposure to ethinylestradiol (EE2), a synthetic estrogen found in oral contraceptives, induces pormotes neoplasic prostate lesions in gerbils (Meriones unguiculatus). Conversely, pequi oil (Pe), extract...
| Publicado en: | International Journal of Environmental Health Research Vol. 34; no. 9; pp. 3073 - 3084 |
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| Autores principales: | , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Sep2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=179108393&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 179108393 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09603123 57L jtl: International Journal of Environmental Health Research issn: 09603123 maglogo: Y pubinfo: dt: Sep2024 vid: 34 iid: 9 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 179108393 174229858 179108393 179108393 10.1080/09603123.2023.2294067 179108393 ppf: 3073 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Histological investigation in aging male and female gerbil prostates after prenatal exposure to pequi (Caryocar brasiliense Cambess) oil and 17α-ethinylestradiol. aug: au: Carvalho e Silva, Patrícia Matias Zuffo, Jéssica Adriane de Souza Mendes, Maria Eduarda Hellou Silva, Lucas Tavares de Souza, João Victor Oliveira Marques Martins, Tracy Martina da Silva Perez, Ana Paula affil: Institute of Agricultural Sciences, Postgraduate Program in Animal Bioscience, Federal University of Jataí, Jataí, Goiás, Brazil sug: subj: Exocrine Glands Prenatal Exposure Delayed Effects Aging Physiology Contraceptives, Oral Adverse Effects Plant Extracts Fruit Plant Oils Adverse Effects Animal Studies Mice Body Weight Epithelium Anatomy and Histology Prostate Anatomy and Histology Descriptive Statistics Funding Source ab: The female prostate, also known as Skene's gland, is present in both humans and rodents. Prenatal exposure to ethinylestradiol (EE2), a synthetic estrogen found in oral contraceptives, induces pormotes neoplasic prostate lesions in gerbils (Meriones unguiculatus). Conversely, pequi oil (Pe), extracted from the Brazilian Cerrado fruit, has antioxidant, anti-inflammatory, and anticancer properties, mitigates risks associated with chronic diseases related to lifestyle and aging. This study evaluates the impact of prenatal exposure to Pe (300 mg/kg) on senile gerbil offspring's male and female prostates under normal conditions and EE2 exposure (15 μg/kg/day). Histological and morphometric analyses revealed that Pe reduced male body weight and prostate epithelial height, along with a thinner muscle layer. In females, EE2 exposure reduced prostatic weight, while Pe exposure lowered epithelial height and the relative stromal compartment volume, increasing the muscle layer. Pequi oil holds potential in mitigating alterations induced by exposure to the endocrine disruptor EE2. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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