Formulation development, in-vitro and ex-vivo evaluation of dry adsorbed solid lipid nanoparticles: an approach of overcoming olanzapine drawbacks.
The present study was aimed at preparing stable dry adsorbed nanoparticles (DANs) of olanzapine (OLZ) loaded solid lipid nanoparticles (SLNs) for sustained release. OLZ SLNs were prepared by hot melt emulsification and ultrasonication using Precirol ATO 5 (PRE) as a solid lipid, combination of Kolli...
| Publicado en: | European Pharmaceutical Journal Vol. 71; no. 1; pp. 1 - 16 |
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| Autores principales: | , , |
| Formato: | equations & formulas pictorial research tables/charts Journal Article |
| Publicado: |
Paradigm Publishing Services
Aug2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=179147444&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 179147444 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 24536725 LF1O jtl: European Pharmaceutical Journal issn: 24536725 maglogo: N pubinfo: dt: Aug2024 vid: 71 iid: 1 pid: 35924 pub: Paradigm Publishing Services artinfo: ui: 179147444 176664382 179147444 179147444 10.2478/afpuc-2024-0004 179147444 ppf: 1 ppct: 15 formats: tig: atl: Formulation development, in-vitro and ex-vivo evaluation of dry adsorbed solid lipid nanoparticles: an approach of overcoming olanzapine drawbacks. aug: au: Hirlekar, Rajashree Momin, Alfiha Bhairy, Srinivas affil: Vivekanand Education Society's College of Pharmacy, Mumbai, Maharashtra INDIA sug: subj: Olanzapine Europe Lipids Nanoparticles Adsorption Drug Development Chemistry, Pharmaceutical Drug Efficacy Biological Availability Permeability In Vitro Studies In Vivo Studies Ultrasonics Surface-Active Agents Analysis Particle Size Olanzapine Pharmacodynamics Animal Studies Poultry Liver Metabolism X-Rays Dosage Forms Nanotechnology Drug Delivery Systems Olanzapine Pharmacokinetics Intestinal Absorption Administration, Oral Spectrophotometry Microscopy, Electron, Scanning Calorimetry Europe Lipids Blood ab: The present study was aimed at preparing stable dry adsorbed nanoparticles (DANs) of olanzapine (OLZ) loaded solid lipid nanoparticles (SLNs) for sustained release. OLZ SLNs were prepared by hot melt emulsification and ultrasonication using Precirol ATO 5 (PRE) as a solid lipid, combination of Kolliphor ELP (KELP) and Tween 80 (T80) as surfactants, after optimising formulation and process variables. The SLN system was subjected to evaluation of particle size, zeta potential, entrapment efficiency (EE), in-vitro drug release and ex-vivo intestinal permeability studies using the chicken intestinal segments (jejunum). Further, these SLNs were converted into stable DANs by adsorbing onto a Neusilin US2 (NUS2) and Avicel CL 611 (ACL) carriers using the granulation-evaporative drying method. The DANs were characterised for redispersion properties, in-vitro drug release, thermal behaviour, crystallinity, and morphology. The SLN and DAN had a particle size of 238.0 nm [0.274 polydispersity index (PdI)] and 302.4 [0.494 PdI] respectively. The zeta potentials of SLN and DAN were found to be −29.3 mV and −26.3 mV, respectively. The SLN had 67% EE, and showed a sustained drug release in various media. The highest permeability of SLNs was observed in ex-vivo permeation model compared to the OLZ suspension, indicating that SLNs have the potential to bypass hepatic metabolism. The adsorption of SLNs onto carriers was confirmed by surface morphology. The DAN had good flow properties and sustained drug release similar to that of SLNs. The X-ray diffraction (XRD) patterns and endothermic peaks confirmed the complete encapsulation of actives in lipid matrices. The encapsulating of OLZ in SLNs and converting it into DAN showed a sustained release and adsorption technique that can be used for improving the stability of NLC dispersion. The DANs can be offered in dosage forms such as filling into sachets, capsules and compressed into tablets. pubtype: Academic Journal doctype: equations & formulas pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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