The role of bile acid metabolism in bone and muscle: from analytics to mechanisms.
Osteoporosis and sarcopenia are both common age-related disorders that are associated with increased morbidity and mortality. Bone and muscle are metabolically very active tissues that require large amounts of energy. Bile acids (BAs), a group of liver-derived steroid compounds, are primarily known...
| Publicado en: | Critical Reviews in Clinical Laboratory Sciences Vol. 61; no. 6; pp. 510 - 529 |
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| Autores principales: | , , , , , , |
| Formato: | pictorial review tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Sep2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=179220494&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 179220494 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10408363 1AV jtl: Critical Reviews in Clinical Laboratory Sciences issn: 10408363 maglogo: Y pubinfo: dt: Sep2024 vid: 61 iid: 6 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 179220494 176030751 179220494 179220494 10.1080/10408363.2024.2323132 179220494 ppf: 510 ppct: 19 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The role of bile acid metabolism in bone and muscle: from analytics to mechanisms. aug: au: Herrmann, Markus Rodriguez-Blanco, Giovanny Balasso, Marco Sobolewska, Katarzyna Semeraro, Maria Donatella Alonso, Nerea Herrmann, Wolfgang affil: Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria sug: subj: Bile Acids and Salts Metabolism Bone and Bones Metabolism Muscle, Skeletal Metabolism Bile Acids and Salts Analysis Bile Acids and Salts Physiology Biochemistry Bone Resorption Mass Spectrometry Bone Remodeling Molecular Structure ab: Osteoporosis and sarcopenia are both common age-related disorders that are associated with increased morbidity and mortality. Bone and muscle are metabolically very active tissues that require large amounts of energy. Bile acids (BAs), a group of liver-derived steroid compounds, are primarily known as emulsifiers that facilitate the resorption of dietary fat and lipids. In addition, they have pleiotropic metabolic functions in lipoprotein and glucose metabolism, inflammation, and intestinal bacterial growth. Through these effects, they are related to metabolic diseases, such as diabetes, hypertriglyceridemia, atherosclerosis, and nonalcoholic steatohepatitis. BAs mediate their metabolic effects through receptor dependent and receptor-independent mechanisms. Emerging evidence suggests that BAs are also involved in bone and muscle metabolism. Under normal circumstances, BAs support bone health by shifting the delicate equilibrium of bone turnover toward bone formation. In contrast, low or excessive amounts of BAs promote bone resorption. In cholestatic liver disease, BAs accumulate in the liver, reach toxic concentrations in the circulation, and thus may contribute to bone loss and muscle wasting. In addition, the measurement of BAs is in rapid evolution with modern mass spectrometry techniques that allow for the detection of a continuously growing number of BAs. This review provides a comprehensive overview of the biochemistry, physiology and measurement of bile acids. Furthermore, it summarizes the existing literature regarding their role in bone and muscle. pubtype: Academic Journal doctype: pictorial review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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