Perturbation walking effects on prefrontal cortical activation and walking performance in older women with and without osteoarthritis: a FNIRS study.
Introduction: Perturbation walking (PW) has been shown to improve gait, however its effect on the cortical control of gait might provide insights on neural mechanisms underlying falls in adults with osteoarthritis. The objective of this study is to investigate the effect of PW on prefrontal cortical...
| Publicado en: | Frontiers in Aging Neuroscience pp. 1 - 10 |
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| Autores principales: | , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Frontiers Media S.A.
2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=179455363&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 179455363 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16634365 BG2U jtl: Frontiers in Aging Neuroscience issn: 16634365 maglogo: N pubinfo: dt: 2024 pid: 40038 pub: Frontiers Media S.A. artinfo: ui: 179455363 179455363 179455363 10.3389/fnagi.2024.1403185 179455363 ppf: 1 ppct: 9 formats: tig: atl: Perturbation walking effects on prefrontal cortical activation and walking performance in older women with and without osteoarthritis: a FNIRS study. aug: au: Bishnoi, Alka Yang Hu Hernandez, Manuel E. affil: Department of Physical Therapy, College of Health Professions and Human Services, Kean University, Union, NJ, United States sug: subj: Walking Prefrontal Cortex Physiology Osteoarthritis In Old Age Community Living In Old Age Gait Analysis Spectroscopy, Near-Infrared Methods Task Performance and Analysis Human Female Aged Middle Age Treadmills Balance, Postural Geriatric Depression Scale Hemoglobins Blood Spearman's Rank Correlation Coefficient Walking Speed Cross Sectional Studies Functional Status Descriptive Statistics Scales Psychological Tests Unpaired T-Tests Post Hoc Analysis Body Mass Index Funding Source Aged: 65+ years Middle Aged: 45-64 years Female ab: Introduction: Perturbation walking (PW) has been shown to improve gait, however its effect on the cortical control of gait might provide insights on neural mechanisms underlying falls in adults with osteoarthritis. The objective of this study is to investigate the effect of PW on prefrontal cortical (PFC) activation in older women with (OA) and without osteoarthritis (HOA). We hypothesized that there would be an increase in PFC activation during PW relative to comfortable walking (CW) and higher increase in PFC activation during PW in HOA compared to OA. Methods: Twenty community-dwelling older women (66.7 ± 5.41 years old) walked on an instrumented treadmill that provided perturbations at pseudorandom intervals between 5-25 s using a counterbalanced design. Functional Near Infrared Spectroscopy was used to quantify PFC oxygenated hemoglobin (HbO2) and deoxyhemoglobin (Hb) levels, while standing prior to the task as a baseline. A linear mixed effects model was conducted to investigate the effects of cohort (HOA vs OA), task (PW vs CW), and their interaction on HbO2 (mM) and Hb (mM) levels. Results: HbO2 and Hb levels differed significantly between CW and PW tasks for both cohorts (P < 0.001) and demonstrated significant task by cohort interaction (P < 0.05). In addition, we found changes in walking performance (stride time, stride length, stride width and stance time) during and after PW. Spearman correlation demonstrated a strong association between increased stance time, increased body mass index and decreased PFC activation during PW. No other significant results were found. Discussion: This study found increase in PFC activation during PW and gait adaptation after a short bout of PW in HOA and OA. This increase in PFC activation was higher in HOA compared to OA, particularly during PW tasks, and was consistent with theory of limitations in mobility affecting neural activation in older adults. Further work remains to examine how pain, obesity, and mobility impacts cortical control in older adults with and without osteoarthritis. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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