The management of critical bone defects: outcomes of a systematic approach.

Background: The reconstruction of segmental long bone defects remains one of 'The holy grails of orthopaedics'. The optimal treatment of which remains a topic of great debate. This study aimed to evaluate the outcomes following the management of critical-sized bone defects using a classification-bas...

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Publicado en:European Journal of Orthopaedic Surgery & Traumatology Vol. 34; no. 6; pp. 3225 - 3232
Autores principales: Tsang, Shao-Ting Jerry, van Rensburg, Adrian Jansen, van Heerden, Jason, Epstein, Gadi Zwe, Venter, Rudolph, Ferreira, Nando
Formato: pictorial research tables/charts Journal Article
Publicado: Springer Nature Aug2024
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Aug2024
      vid: 34
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      pub: Springer Nature
      place: New York, New York
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        10.1007/s00590-024-04050-1
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        atl: The management of critical bone defects: outcomes of a systematic approach.
      aug:
        au:
          Tsang, Shao-Ting Jerry
          van Rensburg, Adrian Jansen
          van Heerden, Jason
          Epstein, Gadi Zwe
          Venter, Rudolph
          Ferreira, Nando
        affil: https://ror.org/05bk57929 Division of Orthopaedic Surgery, Department of Surgical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, 7505, Cape Town, South Africa
      sug:
        subj:
          Bone Transplantation Methods
          Fractures, Open Surgery
          Fracture Fixation Methods
          Algorithms
          Tibial Fractures Surgery
          Treatment Outcomes
          Human
          Male
          Female
          Young Adult
          Adult
          Middle Age
          Retrospective Design
          Prospective Studies
          Fracture Healing
          Orthopedic Surgery
          Sepsis Risk Factors
          Risk Assessment
          Descriptive Statistics
          Confidence Intervals
          Surgery, Reconstructive
          Adult: 19-44 years
          Middle Aged: 45-64 years
          Male
          Female
      ab: Background: The reconstruction of segmental long bone defects remains one of 'The holy grails of orthopaedics'. The optimal treatment of which remains a topic of great debate. This study aimed to evaluate the outcomes following the management of critical-sized bone defects using a classification-based treatment algorithm. Methods: A retrospective review of all patients undergoing treatment for segmental diaphyseal defects of long bones at a tertiary-level limb reconstruction unit between January 2016 and December 2021, was performed. The management of the bone defect was standardised as per the classification by Ferreira and Tanwar (2020). Results: A total of 96 patients (mean age 39.8, SD 15.2) with a minimum six months follow-up were included. Most bone defects were the result of open fractures (75/96) with 67% associated with Gustilo-Anderson IIIB injuries. There was a statistical difference in the likelihood of union between treatment strategies with more than 90% of cases undergoing acute shortening and bone transport achieving union and only 72% of cases undergoing the induced membrane technique consolidating (p = 0.049). Of those defects that consolidated, there was no difference in the time to bone union between strategies (p = 0.308) with an overall median time to union 8.33 months (95% CI 7.4 – 9.2 months). The induced membrane technique was associated with a 40% risk of sepsis. Conclusion: This study reported the outcomes of a standardised approach to the management of critical-sized bone defects. Whilst overall results were supportive of this approach, the outcomes associated with the induced membrane technique require further refinement of its indications in the management of critical-sized bone defects. Level of evidence: 4.
      pubtype: Academic Journal
      doctype:
        pictorial
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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