Examining the association of immunosuppressants and wound healing: a narrative review.
Objective To review how different classes of immunosuppressants affect wound healing. Data Sources A literature search was conducted in PubMed, Google Scholar, and the University of Calgary Health Sciences Library. Study Selection The researchers initially screened article titles using key words suc...
| Publicado en: | World Council of Enterostomal Therapists Journal Vol. 44; no. 3; pp. 12 - 20 |
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| Autores principales: | , , |
| Formato: | review tables/charts Journal Article |
| Publicado: |
Cambridge Publishing
Sep2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=179544209&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 179544209 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 08194610 YUD jtl: World Council of Enterostomal Therapists Journal issn: 08194610 maglogo: N pubinfo: dt: Sep2024 vid: 44 iid: 3 pid: 66266 pub: Cambridge Publishing artinfo: ui: 179544209 179544209 179544209 10.33235/wcet.44.3.12-19 179544209 ppf: 12 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Examining the association of immunosuppressants and wound healing: a narrative review. aug: au: Appoo, Aria Christensen, Brandon L. Somayaji, Ranjani affil: Medical Student, University of Oxford, Oxford, United Kingdom sug: subj: Wound Healing Drug Effects Immunosuppressive Agents Therapeutic Use Immunosuppressive Agents Classification Immunosuppressive Agents Pharmacodynamics Immunosuppression Hydrolases Antibodies, Monoclonal Antimetabolites Adrenal Cortex Hormones Fibroblasts Drug Effects Immunosuppressive Agents Administration and Dosage Dose-Response Relationship, Drug MTOR Inhibitors Drug Effects Cell Proliferation Drug Effects Kidney Transplantation Autoimmune Diseases Drug Therapy ab: Objective To review how different classes of immunosuppressants affect wound healing. Data Sources A literature search was conducted in PubMed, Google Scholar, and the University of Calgary Health Sciences Library. Study Selection The researchers initially screened article titles using key words such as "immunosuppressive medication," "wound healing," and "immunosuppression." Articles in which the title and/or abstract contained these key words, that addressed wound healing related to immunosuppressant medications, and were published after 2000 were included in the review. When human data were not available for an immunosuppressant (class), animal studies were included. Data Extraction The 61 included articles underwent full text review and summarization. Data Synthesis: All included studies were summarized descriptively including immunosuppressive mechanism of action, study participants or subjects, and evidence of effects on wound healing. Conclusions Corticosteroids and mechanistic target of rapamycin inhibitors most consistently demonstrate detrimental effects on wound healing. For other classes of immunosuppressants, evidence is limited with varying effects on wound healing described. Larger, high-quality studies are required to better understand the effects of immunosuppressants, including those with new mechanisms of action, to identify those with the most impact on wound healing. pubtype: Academic Journal doctype: review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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