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B12 Hypervitaminemia: Pathogenetic Pathways and Clinical Implications.

Background. Pathological changes in vitamin B12 levels are a common laboratory finding. The increase in serum vitamin B12 levels is termed B12 hypervitaminemia, often perceived as a benign disorder, leading to its underestimation. Objective.This paper aims to examine the potential pathogenetic mecha...

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Published in:International Journal of Caring Sciences Vol. 17; no. 2; pp. 1178 - 1190
Main Author: Kyriazi, Vasiliki
Format: review tables/charts Journal Article
Published: International Journal of Caring Sciences May-Aug2024
Online Access:View this record in EBSCOhost
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      dt: May-Aug2024
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      pub: International Journal of Caring Sciences
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        atl: B12 Hypervitaminemia: Pathogenetic Pathways and Clinical Implications.
      aug:
        au: Kyriazi, Vasiliki
        affil: Hematologist, Hematology Department, General Hospital Korgialenio-Benakio, Athens, Greece
      sug:
        subj:
          Vitamin B12 Blood
          Vitamin B12 Metabolism
          Deficiency Diseases
          Hematologic Neoplasms
          Liver Diseases
          Kidney Failure, Acute
          Dietary Supplementation
          Carrier Proteins
          Autoimmune Diseases
          Communicable Diseases
          Mental Disorders Diagnosed in Childhood
      ab: Background. Pathological changes in vitamin B12 levels are a common laboratory finding. The increase in serum vitamin B12 levels is termed B12 hypervitaminemia, often perceived as a benign disorder, leading to its underestimation. Objective.This paper aims to examine the potential pathogenetic mechanisms and the association of vitamin B12 excess with various diseases. Methodology. A literature search was conducted using the PubMed, DOAJ, and Google Scholar databases. The search was focused on original articles, review papers, and reference lists published in English since 2000. Results. Increased vitamin B12 levels are encountered in hematological disorders, solid tumors, renal and hepatic diseases, as well as inflammatory conditions. Vitamin B12 supplements increase the levels and can exacerbate underlying pathological conditions. The pathophysiology involves disturbances in the biology and metabolism of vitamin B12 and its carrier proteins. Falsely elevated values can arise due to interferences in quantitative assays. Elevated vitamin B12 may represent an incidental finding, accompany findings of underlying disease, and coexist with manifestations of functional deficiency. Conclusion. Elevated vitamin B12 may serve as an early indicator for the diagnosis and monitoring of serious diseases. Understanding the underlying pathogenetic mechanisms and establishing diagnostic algorithms are crucial areas for future research.
      pubtype: Academic Journal
      doctype:
        review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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