The Clinical Effect of a Propolis and Mangosteen Extract Complex in Subjects with Gingivitis: A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial.
This study investigated the efficacy and safety of a propolis–mangosteen extract complex (PMEC) on gingival health in patients with gingivitis and incipient periodontitis. A multicentered, randomized, double-blind, placebo-controlled trial involving 104 subjects receiving either PMEC or placebo for...
| Publicado en: | Nutrients Vol. 16; no. 17; pp. 3000 - 3017 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
MDPI
Sep2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=179648474&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 179648474 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20726643 B0TT jtl: Nutrients issn: 20726643 maglogo: N pubinfo: dt: Sep2024 vid: 16 iid: 17 pid: 97109 pub: MDPI artinfo: ui: 179648474 179648474 179648474 10.3390/nu16173000 179648474 ppf: 3000 ppct: 17 formats: tig: atl: The Clinical Effect of a Propolis and Mangosteen Extract Complex in Subjects with Gingivitis: A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial. aug: au: Jung, Jae-Suk Choi, Geum-Hee Lee, Heelim Ko, Youngkyung Ji, Suk affil: Department of Periodontology, Institute of Oral Health Science, Ajou University School of Medicine, Suwon 16499, Republic of Korea sug: subj: Propolis Therapeutic Use Plant Extracts Therapeutic Use Gingivitis Drug Therapy Treatment Outcomes Periodontitis Drug Therapy Drug Efficacy Patient Safety Human Funding Source Randomized Controlled Trials Random Assignment Pretest-Posttest Control Group Design Comparative Studies Double-Blind Studies Multicenter Studies Inflammation Biological Markers Gingiva Exudates and Transudates Interleukins Blood Dinoprostone Blood Peptide Hydrolases Blood Descriptive Statistics Inflammation Prevention and Control Periodontitis Prevention and Control Inflammation Mediators Antiinflammatory Agents Therapeutic Use ab: This study investigated the efficacy and safety of a propolis–mangosteen extract complex (PMEC) on gingival health in patients with gingivitis and incipient periodontitis. A multicentered, randomized, double-blind, placebo-controlled trial involving 104 subjects receiving either PMEC or placebo for eight weeks was conducted. The primary focus was on the changes in inflammatory biomarkers from gingival crevicular fluid (GCF), with clinical parameters as secondary outcomes. The results revealed that the PMEC group showed a significantly reduced expression of all measured GCF biomarkers compared to the placebo group (p < 0.0001) at 8 weeks, including substantial reductions in IL-1β, PGE2, MMP-8, and MMP-9 levels compared to the baseline. While clinical parameters trended towards improvement in both groups, the intergroup differences were not statistically significant. No significant adverse events were reported, indicating a favorable safety profile. These findings suggest that PMEC consumption can attenuate gingival inflammation and mitigate periodontal tissue destruction by modulating key inflammatory mediators in gingival tissue. Although PMEC shows promise as a potential adjunctive therapy for supporting gingival health, the discrepancy between biomarker improvements and clinical outcomes warrants further investigation to fully elucidate its therapeutic potential in periodontal health management. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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