The Burden Borne by Urease.
The article reports that to appreciate the power of an enzyme as a catalyst, and its potential sensitivity to inhibition by an ideal transition-state analogue, it is useful to know the rate of the spontaneous reaction in the absence of a catalyst. According to the authors, it would be of interest to...
| Publicado en: | Journal of the American Chemical Society Vol. 127; no. 31; pp. 10828 - 10830 |
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| Autores principales: | , , |
| Formato: | Artículo |
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American Chemical Society
8/10/2005
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=hlh&AN=17967632&site=ehost-live header: @attributes: shortDbName: hlh uiTerm: 17967632 longDbName: Humanities International Complete uiTag: AN controlInfo: bkinfo: jinfo: jid: 00027863 ACS jtl: Journal of the American Chemical Society issn: 00027863 maglogo: N pubinfo: dt: 8/10/2005 vid: 127 iid: 31 pid: 997 pub: American Chemical Society artinfo: ui: 17967632 10.1021/ja0525399 ppf: 10828 ppct: 2 formats: tig: atl: The Burden Borne by Urease. aug: au: Callahan, Brian P. Yang Yuan Wolfenden, Richard affil: Department of Biochemistry & Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599. su: Enzymes Catalysis Physical & theoretical chemistry Surface chemistry Hydrolases Nickel sug: subj: Enzymes Catalysis Physical & theoretical chemistry Surface chemistry Hydrolases Nickel ab: The article reports that to appreciate the power of an enzyme as a catalyst, and its potential sensitivity to inhibition by an ideal transition-state analogue, it is useful to know the rate of the spontaneous reaction in the absence of a catalyst. According to the authors, it would be of interest to know how these rate enhancements compare with those produced by other hydrolases that may be related in their mechanism of action. Urease appears to be unique among hydrolases in containing two nickel atoms, which presumably assist this enzyme in grappling effectively with this unusually simple substrate. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y dt: @attributes: year: 2005 holdings: @attributes: islocal: N |
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