Evaluation of Antibiotic Allergy in the Ambulatory Setting Using a Standardized Questionnaire.
Patients are sometimes mislabeled as having an immune-mediated antibiotic allergy in their medical records. Therefore, the aim of this study was to investigate the prevalence of subjects with non-immune mediated reactions to antibiotics using a standardized questionnaire. Subjects aged 18 years and...
| Publicado en: | Journal of Pharmacy Practice Vol. 37; no. 5; pp. 1121 - 1127 |
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| Autores principales: | , , , , , |
| Formato: | questionnaire/scale research tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
Oct2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=179737434&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 179737434 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 08971900 NL1 jtl: Journal of Pharmacy Practice issn: 08971900 maglogo: Y pubinfo: dt: Oct2024 vid: 37 iid: 5 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 179737434 174868598 179737434 179737434 10.1177/08971900241227977 179737434 ppf: 1121 ppct: 6 formats: tig: atl: Evaluation of Antibiotic Allergy in the Ambulatory Setting Using a Standardized Questionnaire. aug: au: Yi, Sarah M. Barsanti-Sekhar, Mary Wozniak, Amy W. Santarossa, Maressa Adams, Jenna Albarillo, Fritzie affil: Stritch School of Medicine, Maywood, IL, USA sug: subj: Ambulatory Care Facilities Antibiotics Adverse Effects Immune System Drug Effects Drug Hypersensitivity Risk Factors Risk Assessment Questionnaires Human Immunity Outpatient Service Illinois Patient Attitudes Confidence Intervals Adverse Drug Event Penicillins Sulfonamides Antiinfective Agents, Fluoroquinolone Medication History Descriptive Statistics Antibiotics Contraindications Funding Source Adolescence Adult Middle Age Aged Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years ab: Patients are sometimes mislabeled as having an immune-mediated antibiotic allergy in their medical records. Therefore, the aim of this study was to investigate the prevalence of subjects with non-immune mediated reactions to antibiotics using a standardized questionnaire. Subjects aged 18 years and older with a documented antibiotic allergy were identified and recruited from 2 outpatient clinics in the greater Chicago area. Subjects completed a standardized questionnaire during a single visit regarding their previous adverse reaction to an antibiotic. For subjects with multiple documented antibiotic allergies, 1 questionnaire was filled out for each antibiotic allergy. Investigators subsequently evaluated the questionnaire responses to determine whether the adverse reaction was a true immune-mediated allergic reaction or an adverse drug reaction. A total of 98 subjects were recruited with completion of 159 questionnaires. Eighteen subjects (18.37%, 95% CI: 10.7%, 26.3%) had antibiotic allergy labels with no corresponding immune-mediated reaction history. There were 35 allergy labels (22.0%, 95% CI: 14.7%, 29.4%) that were unlikely to be immune-mediated. Antibiotics with the highest percentage of clinical histories that were unlikely to be immune-mediated were macrolides (8 of 11 subjects), nitrofurantoin (1 of 2 subjects), and amoxicillin/clavulanate (2 of 8 subjects). The most common antibiotic allergy labels were penicillin (43 of 159 subjects), sulfonamides (25 of 159 subjects), and fluoroquinolones (21 of 159 subjects). Identification of adverse reactions to antibiotics that are unlikely to be immune-mediated can be accomplished using a standardized questionnaire in the outpatient setting. Improved identification of low-risk antibiotic allergy labels can guide de-labeling initiatives to improve antibiotic prescribing. pubtype: Academic Journal doctype: questionnaire/scale research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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