Rest-fMRI—A Potential Substitute for Task-fMRI?
Objective The aim of this study was to assess the reliability of resting-state functional magnetic resonance imaging (rest-fMRI) in mapping language areas for preoperative planning, versus standard task-based techniques, which are at times difficult to perform in clinical settings. Our study also ai...
| Publicado en: | Indian Journal of Radiology & Imaging Vol. 34; no. 4; pp. 628 - 636 |
|---|---|
| Autores principales: | , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Thieme Medical & Scientific Publishers Private Limited
2024
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=179786444&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 179786444 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09713026 1CQM jtl: Indian Journal of Radiology & Imaging issn: 09713026 maglogo: N pubinfo: dt: 2024 vid: 34 iid: 4 pid: 65383 pub: Thieme Medical & Scientific Publishers Private Limited artinfo: ui: 179786444 179786444 179786444 10.1055/s-0044-1786723 179786444 ppf: 628 ppct: 8 formats: tig: atl: Rest-fMRI—A Potential Substitute for Task-fMRI? aug: au: Gupta, Santosh S. Sriram, Rithika Mulani, Smruti affil: Department of Radiology, P. D. Hinduja Hospital and Medical Research Centre, Mumbai, Maharashtra, India sug: subj: Brain Physiology Brain Mapping Methods Magnetic Resonance Imaging Methods Relaxation Task Performance and Analysis Language Processing Evaluation Neural Pathways Analysis Human Data Analysis Software Functional Connectivity Neurosurgery Grammar Descriptive Statistics Child Adult Semantics Child: 6-12 years Adult: 19-44 years ab: Objective The aim of this study was to assess the reliability of resting-state functional magnetic resonance imaging (rest-fMRI) in mapping language areas for preoperative planning, versus standard task-based techniques, which are at times difficult to perform in clinical settings. Our study also aimed to evaluate the overlap between language areas identified through rest-fMRI and the standard task-fMRI, in neurosurgical cases. Materials and Methods Using a seed-based analysis of rest-fMRI with multiple template seeds, we identified functionally connected language regions in patients undergoing preoperative language mapping. Four language task paradigms (word, verb, picture, and semantics) were evaluated. We quantified the degree of overlap between language areas identified on rest-fMRI and task-fMRI, categorizing the results as more than 50% or less than 50% overlap. Results Seventy-seven percent of patients demonstrated an overlap exceeding 50% between rest- and task-fMRI maps, with the left Broca's area being the most frequently observed region of overlap. This finding was noted even in cases with lesions in Broca's or Wernicke's areas, highlighting the method's robustness. The verb task showed the best blood-oxygen-level dependent activity and overlap with rest-fMRI, highlighting its reliability. To identify a specific language area, the contralateral seed of the same area most commonly displayed connectivity with the area of interest. Conclusion Our findings demonstrate the potential of using rest-fMRI in accurately mapping eloquent language areas, in clinical settings The strong concordance observed, especially in the left Broca's area, underscores the reliability of this method. Further research and larger studies are essential to validate these results, potentially establishing the use of routine rest-fMRI, in clinical preoperative workup. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|