The correlation between brain structure characteristics and emotion regulation ability in children at high risk of autism spectrum disorder.
As indicated by longitudinal observation, autism has difficulty controlling emotions to a certain extent in early childhood, and most children's emotional and behavioral problems are further aggravated with the growth of age. This study aimed at exploring the correlation between white matter and whi...
| Publicado en: | European Child & Adolescent Psychiatry Vol. 33; no. 9; pp. 3247 - 3263 |
|---|---|
| Autores principales: | , , , , , , , |
| Formato: | diagnostic images equations & formulas pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Sep2024
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=179872995&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 179872995 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Sep2024 vid: 33 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 179872995 175597627 179872995 179872995 10.1007/s00787-024-02369-y 179872995 ppf: 3247 ppct: 16 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The correlation between brain structure characteristics and emotion regulation ability in children at high risk of autism spectrum disorder. aug: au: Ding, Ning Fu, Linyan Qian, Lu Sun, Bei Li, Chunyan Gao, Huiyun Lei, Tianyu Ke, Xiaoyan affil: Child Mental Health Research Center, The Affiliated Brain Hospital of Nanjing Medical University, 210029, Nanjing, China sug: subj: Brain Anatomy and Histology Emotional Regulation In Infancy and Childhood Autism Spectrum Disorder Risk Factors Risk Assessment Child Behavior White Matter Pathology Machine Learning Methods Brain Radiography Human Male Female Child, Preschool Funding Source Prospective Studies Nonexperimental Studies Skull Radiography Comparative Studies Regression Hippocampus Magnetic Resonance Imaging Methods Infant Chi Square Test Data Analysis Software T-Tests Linear Regression Descriptive Statistics Child, Preschool: 2-5 years Infant: 1-23 months Male Female ab: As indicated by longitudinal observation, autism has difficulty controlling emotions to a certain extent in early childhood, and most children's emotional and behavioral problems are further aggravated with the growth of age. This study aimed at exploring the correlation between white matter and white matter fiber bundle connectivity characteristics and their emotional regulation ability in children with autism using machine learning methods, which can lay an empirical basis for early clinical intervention of autism. Fifty-five high risk of autism spectrum disorder (HR-ASD) children and 52 typical development (TD) children were selected to complete the skull 3D-T1 structure and diffusion tensor imaging (DTI). The emotional regulation ability of the two groups was compared using the still-face paradigm (SFP). The classification and regression models of white matter characteristics and white matter fiber bundle connections of emotion regulation ability in the HR-ASD group were built based on the machine learning method. The volume of the right amygdala (R2 = 0.245) and the volume of the right hippocampus (R2 = 0.197) affected constructive emotion regulation strategies. FA (R2 = 0.32) and MD (R2 = 0.34) had the predictive effect on self-stimulating behaviour. White matter fiber bundle connection predicted constructive regulation strategies (positive edging R2 = 0.333, negative edging R2 = 0.334) and mother-seeking behaviors (positive edging R2 = 0.667, negative edging R2 = 0.363). The emotional regulation ability of HR-ASD children is significantly correlated with the connections of multiple white matter fiber bundles, which is a potential neuro-biomarker of emotional regulation ability. pubtype: Academic Journal doctype: diagnostic images equations & formulas pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|