Cranial bone thickness and density anomalies quantified from CT images can identify chronic increased intracranial pressure.
Purpose: The diagnosis of chronic increased intracranial pressure (IIP)is often based on subjective evaluation or clinical metrics with low predictive value. We aimed to quantify cranial bone changes associated with pediatric IIP using CT images and to identify patients at risk. Methods: We retrospe...
| Publicado en: | Neuroradiology Vol. 66; no. 10; pp. 1817 - 1829 |
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| Autores principales: | , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Oct2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=179873451&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 179873451 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Oct2024 vid: 66 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 179873451 177829259 179873451 179873451 10.1007/s00234-024-03393-0 179873451 ppf: 1817 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Cranial bone thickness and density anomalies quantified from CT images can identify chronic increased intracranial pressure. aug: au: Liu, Jiawei Chaij, Jasmine Linguraru, Marius George French, Brooke Keating, Robert Alexander, Allyson L. Porras, Antonio R. affil: Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA sug: subj: Skull Abnormalities Bone Density Tomography, X-Ray Computed Chronic Disease Intracranial Pressure Pediatric Care Human Retrospective Design Record Review Craniosynostoses Confidence Intervals Sensitivity and Specificity Female Male Child, Preschool Child, Preschool: 2-5 years Female Male ab: Purpose: The diagnosis of chronic increased intracranial pressure (IIP)is often based on subjective evaluation or clinical metrics with low predictive value. We aimed to quantify cranial bone changes associated with pediatric IIP using CT images and to identify patients at risk. Methods: We retrospectively quantified local cranial bone thickness and mineral density from the CT images of children with chronic IIP and compared their statistical differences to normative children without IIP adjusting for age, sex and image resolution. Subsequently, we developed a classifier to identify IIP based on these measurements. Finally, we demonstrated our methods to explore signs of IIP in patients with non-syndromic sagittal craniosynostosis (NSSC). Results: We quantified a significant decrease of bone density in 48 patients with IIP compared to 1,018 normative subjects (P <.001), but no differences in bone thickness (P =.56 and P =.89 for age groups 0–2 and 2–10 years, respectively). Our classifier demonstrated 83.33% (95% CI: 69.24%, 92.03%) sensitivity and 87.13% (95% CI: 84.88%, 89.10%) specificity in identifying patients with IIP. Compared to normative subjects, 242 patients with NSSC presented significantly lower cranial bone density (P <.001), but no differences were found compared to patients with IIP (P =.57). Of patients with NSSC, 36.78% (95% CI: 30.76%, 43.22%) presented signs of IIP. Conclusion: Cranial bone changes associated with pediatric IIP can be quantified from CT images to support earlier diagnoses of IIP, and to study the presence of IIP secondary to cranial pathology such as non-syndromic sagittal craniosynostosis. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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