Cognitive impairment in adolescent and adult-onset psychosis: a comparative study.
Background: Cognitive impairment presents in both adolescent-onset(ado-OP) and adult-onset psychosis(adu-OP). Age and neurodevelopmental factors likely contribute to cognitive differences. This study aimed to characterize cognitive functions in ado-OP compared to adu-OP in a clinical population with...
| Publicado en: | Child & Adolescent Psychiatry & Mental Health Vol. 18; no. 1; pp. 1 - 12 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
BioMed Central
9/28/2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=179970724&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 179970724 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17532000 78JH jtl: Child & Adolescent Psychiatry & Mental Health issn: 17532000 maglogo: N pubinfo: dt: 9/28/2024 vid: 18 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 179970724 179970724 179970724 10.1186/s13034-024-00815-y 179970724 ppf: 1 ppct: 11 formats: tig: atl: Cognitive impairment in adolescent and adult-onset psychosis: a comparative study. aug: au: Zhang, TianHong Wei, YanYan Tang, XiaoChen Xu, LiHua Cui, HuiRu Hu, YeGang Liu, HaiChun Wang, ZiXuan Chen, Tao Li, ChunBo Wang, JiJun affil: Shanghai Mental Health Center, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention (20DZ2253800), Shanghai Key Laboratory of Psychotic Disorders (No.13dz2260500), Shanghai Jiaotong University School of Medicine, 600 Wanping Nan Road, 200030, Shanghai, China sug: subj: Cognition Disorders In Adolescence Psychotic Disorders In Adulthood Cognition Evaluation Age of Onset Human China Female Male Adolescence Adult Comparative Studies DSM Scales Structured Interview Psychological Tests Neuropsychological Tests Sociodemographic Factors Effect Size Neurosciences Spearman's Rank Correlation Coefficient Correlation Coefficient Logistic Regression Confidence Intervals Data Analysis Software Odds Ratio Descriptive Statistics Funding Source Adolescent: 13-18 years Adult: 19-44 years Female Male ab: Background: Cognitive impairment presents in both adolescent-onset(ado-OP) and adult-onset psychosis(adu-OP). Age and neurodevelopmental factors likely contribute to cognitive differences. This study aimed to characterize cognitive functions in ado-OP compared to adu-OP in a clinical population with drug-naive first-episode psychosis(FEP). Methods: A total of 788 drug-naive patients with FEP and 774 sex- and age-matched healthy controls(HCs) were included. Participants were divided into four groups by whether they were under or over 21 years of age: adolescent-onset FEP(ado-FEP, n = 380), adult-onset FEP(adu-FEP, n = 408), adolescent HC(ado-HC, n = 334), and adult HC(adu-HC, n = 440). Comprehensive cognitive assessments were performed using the MATRICS Cognitive Consensus Battery(MCCB), covers six cognitive domains: speed of processing, attention/vigilance, working memory, verbal learning, visual learning, reasoning, and problem-solving. Data analyses were conducted using correlation analyses and binary logistic regression. Results: The patterns of cognitive domain differences between ado-FEP and adu-FEP were found to be similar to those between ado-HC and adu-HC, whereas cognitive impairments appeared to be more pronounced in patients with adu-OP than ado-OP. The mazes subtest had the maximum effect size(ES) in the FEP(ES = 0.37) and HC(ES = 0.30) groups when comparing the adolescent and adult groups. Cognitive subtests were mostly significantly correlated with negative symptoms, especially for adolescents with FEP, in which all the subtests were significantly correlated with negative symptoms in the ado-FEP group. Better performance in the domains of spatial cognition and problem-solving abilities was more likely in the ado-FEP group than in the adu-FEP group. Conclusions: These findings suggest cognitive differences between adolescents and adults but similar patterns of affected domains in HCs and patients with FEP. Therefore, the development of targeted cognitive interventions tailored to the specific needs of different age groups appears warranted. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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