Is End-Stage Renal Disease Tumor Suppressive? Dispelling the Myths.
Simple Summary: End-stage renal disease (ESRD) is a life-threatening condition that necessitates renal replacement therapies such as dialysis. ESRD is believed to increase cancer risk and cancer mortality rate; however, data on cancer risk and cancer-specific mortality in patients with ESRD present...
| Publicado en: | Cancers Vol. 16; no. 18; pp. 3135 - 3147 |
|---|---|
| Autor principal: | |
| Formato: | review tables/charts Journal Article |
| Publicado: |
MDPI
Sep2024
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=180008812&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 180008812 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20726694 B74B jtl: Cancers issn: 20726694 maglogo: N pubinfo: dt: Sep2024 vid: 16 iid: 18 pid: 97109 pub: MDPI artinfo: ui: 180008812 180008812 180008812 10.3390/cancers16183135 180008812 ppf: 3135 ppct: 12 formats: tig: atl: Is End-Stage Renal Disease Tumor Suppressive? Dispelling the Myths. aug: au: Migita, Toshiro affil: Tokyo Nephrology Clinic, Tokyo 170-0003, Japan sug: subj: Kidney Failure, Chronic Complications Neoplasms Epidemiology Disease Progression Kidney Failure, Chronic Pathology Risk Assessment Neoplasms Risk Factors Kidney Neoplasms Neoplasms Mortality Neoplasm Invasiveness Neoplasm Metastasis Urologic Neoplasms ab: Simple Summary: End-stage renal disease (ESRD) is a life-threatening condition that necessitates renal replacement therapies such as dialysis. ESRD is believed to increase cancer risk and cancer mortality rate; however, data on cancer risk and cancer-specific mortality in patients with ESRD present multiple statistical issues, including sampling errors, bias, and confounding factors, falsely depicting high cancer incidence. Only renal cell and urothelial cancers are driven by ESRD. However, cancer-specific mortality is generally lower in patients with ESRD than in the general population, which corresponds to the fact that cancers arising from ESRD are generally less aggressive and have low metastatic potential. ESRD damages not only normal but also malignant cells in multiple stages of cancer development. This review highlights the potential anticancer effects of ESRD, proposing a reconsideration of the hypothesis that ESRD promotes cancer development and progression. The prevalence of end-stage renal disease is increasing worldwide. Malignancies accompanying end-stage renal disease are detected in approximately 120 individuals per 10,000 person-years. Most studies have suggested that end-stage renal disease causes carcinogenesis and promotes tumor development; however, this theory remains questionable. Contrary to the theory that end-stage renal disease is predominantly carcinogenic, recent findings have suggested that after controlling for biases and sampling errors, the overall cancer risk in patients with end-stage renal disease might be lower than that in the general population, except for renal and urothelial cancer risks. Additionally, mortality rates associated with most cancers are lower in patients with end-stage renal disease than in the general population. Several biological mechanisms have been proposed to explain the anticancer effects of end-stage renal disease, including premature aging and senescence, enhanced cancer immunity, uremic tumoricidal effects, hormonal and metabolic changes, and dialysis therapy-related factors. Despite common beliefs that end-stage renal disease exacerbates cancer risk, emerging evidence suggests potential tumor-suppressive effects. This review highlights the potential anticancer effects of end-stage renal disease, proposing reconsideration of the hypothesis that end-stage renal disease promotes cancer development and progression. pubtype: Academic Journal doctype: review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|