Sex disparities in cardiac sarcoidosis patients undergoing implantable cardioverter‐defibrillator implantation.
Introduction: In patients with cardiac sarcoidosis (CS), implantable cardioverter‐defibrillators (ICDs) are important for preventing sudden cardiac death. This study aimed to investigate sex disparities in CS patients undergoing ICD implantation. Methods: The 2016–2020 National Inpatient Sample (NIS...
| Publicado en: | Pacing & Clinical Electrophysiology Vol. 47; no. 10; pp. 1394 - 1404 |
|---|---|
| Autores principales: | , , , , , , , , , , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Oct2024
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=180170748&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 180170748 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01478389 4F8 jtl: Pacing & Clinical Electrophysiology issn: 01478389 maglogo: Y pubinfo: dt: Oct2024 vid: 47 iid: 10 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 180170748 178676301 180170748 180170748 10.1111/pace.15051 180170748 ppf: 1394 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Sex disparities in cardiac sarcoidosis patients undergoing implantable cardioverter‐defibrillator implantation. aug: au: Ahmed, Raheel Jamil, Yumna Ramphul, Kamleshun Mactaggart, Sebastian Bilal, Maham Singh Dulay, Mansimran Shi, Rui Azzu, Alessia Okafor, Joseph Memon, Rahat A Sakthivel, Hemamalini Khattar, Rajdeep Wells, Athol Umfrey Baksi, John Arun Wechalekar, Kshama Kouranos, Vasilis Chahal, Anwar Sharma, Rakesh affil: Royal Brompton Hospital, part of Guy's and St Thomas' NHS Foundation Trust, London, UK sug: subj: Sarcoidosis Therapy Sarcoidosis Epidemiology Defibrillators, Implantable Adverse Effects Sex Factors Human Male Female Middle Age Aged Inpatients United States Retrospective Design Record Review Death, Sudden, Cardiac Prevention and Control Death, Sudden, Cardiac Epidemiology Myocardial Diseases Therapy Cardiac Patients Hospitalization Statistics and Numerical Data Treatment Outcomes Atrial Fibrillation Epidemiology Major Adverse Cardiac Events Risk Factors Descriptive Statistics Comparative Studies Odds Ratio Confidence Intervals Hospital Mortality Prevalence Incidence Comorbidity Questionnaires Kidney Failure, Acute Epidemiology Length of Stay Health Facility Charges Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Introduction: In patients with cardiac sarcoidosis (CS), implantable cardioverter‐defibrillators (ICDs) are important for preventing sudden cardiac death. This study aimed to investigate sex disparities in CS patients undergoing ICD implantation. Methods: The 2016–2020 National Inpatient Sample (NIS) database compared the characteristics and outcomes of males and females with CS receiving ICDs. Results: Among 760 CS patients who underwent inpatient ICD implantation, 66.4% were male. Males were younger (55.0 vs. 56.9 years, p <.01), had higher rates of diabetes (31.7% vs. 21.6%, p <.01) and chronic kidney disease (CKD) (16.8% vs. 7.8%, p <.01) but lower prevalence of atrial fibrillation (AF) (11.9% vs. 23.5%, p <.01), sick sinus syndrome (4.0% vs. 7.8%, p =.024), ventricular fibrillation (VF) (9.9% vs. 15.7%, p =.02), and black ancestry (31.9% vs. 58.0%, p <.01). Unadjusted major adverse cardiovascular events (MACE), defined as a composite of in‐hospital death, myocardial infarction (MI), and ischemic stroke, was higher in females (11.8% vs. 6.9%, p =.024), but when adjusted for age and tCharlson Comorbidity Index (CCI), females demonstrated significantly lower odds of experiencing MACE (aOR: 0.048, 95% CI: 0.006–0.395, p =.005). Incidence of acute kidney injury (AKI) post‐ICD was significantly lower in females (15.7% vs. 23.8%, p =.01) as was the adjusted odds (aOR: 0.282, 95% CI: 0.146–0.546, p <.01). There was comparable mean length of stay and hospital charges. Conclusion: ICD utilization in CS patients is more common among males, who have a higher prevalence of diabetes and CKD but a lower prevalence of AF, sick sinus syndrome, and VF. Adjusted MACE and AKI were significantly lower in females. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|