Association between tryptophan concentrations and the risk of developing cardiovascular diseases: a systematic review and meta-analysis.
Background: Metabolic regulation of various amino acids have been proven to be effective in preventing cardiovascular disease (CVD). The impact of tryptophan, an essential amino acid, on the risk of developing CVD has not been fully elucidated. Aims: The aim of this meta-analysis was to systematical...
| Publicado en: | Nutrition & Metabolism Vol. 21; no. 1; pp. 1 - 8 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
BioMed Central
10/15/2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=180268516&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 180268516 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17437075 1CYX jtl: Nutrition & Metabolism issn: 17437075 maglogo: N pubinfo: dt: 10/15/2024 vid: 21 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 180268516 180268516 180268516 10.1186/s12986-024-00857-1 180268516 ppf: 1 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Association between tryptophan concentrations and the risk of developing cardiovascular diseases: a systematic review and meta-analysis. aug: au: Zhang, Jing Jiang, Xia Pang, Bo Li, Dongyun Kang, Longfei Zhou, Tengda Wang, Boyu Zheng, Lihua Zhou, Chuan-min Zhang, Lei affil: Department of General Surgery, Department of Vascular Surgery, The First Hospital of Hebei Medical University, Shijiazhuang, China sug: subj: Cardiovascular Diseases Prevention and Control Tryptophan Metabolism Tryptophan Blood Tryptophan Urine Cardiovascular Risk Factors Biological Markers Risk Assessment Human Male Adult Middle Age Aged Aged, 80 and Over Systematic Review Meta Analysis PubMed Embase Cochrane Library Coronary Arteriosclerosis Heart Failure Peripheral Vascular Diseases Confidence Intervals Descriptive Statistics Funding Source Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male ab: Background: Metabolic regulation of various amino acids have been proven to be effective in preventing cardiovascular disease (CVD). The impact of tryptophan, an essential amino acid, on the risk of developing CVD has not been fully elucidated. Aims: The aim of this meta-analysis was to systematically review evidence of the effects of tryptophan on CVD risk. Methods: The PubMed, Embase, Web of Science, Cochrane Library, and China National Knowledge Infrastructure (CNKI) databases were searched to collect relevant trials from inception to August 2024. The means and hazard ratios (HRs) were extracted and pooled. Subgroup analysis was performed to identify pooled effect estimates, and sensitivity analysis was conducted to assess the robustness of the pooled estimates. Results: Data were collected from 34,370 people under follow-up for CVD events in 13 studies, including cohort studies and case-control studies. They were categorized into three groups on the basis of sample type and indicators: the plasma tryptophan level group, the plasma tryptophan CVD hazard group, and the urinary tryptophan CVD hazard group. The CVD included in this study were coronary artery disease, heart failure, and peripheral artery disease. Twelve studies on plasma tryptophan were meta-analyzed. The plasma tryptophan levels in CVD patients were generally lower than those in individuals without CVD (SMD = -8.57, 95%CI (-15.77, -1.37), P = 0.02). Decreased circulating tryptophan levels are associated with cardiovascular disease risk (HR = 0.85, 95%CI (0.78, 0.92), P < 0.00001). Conclusions: Decreased circulating tryptophan levels are associated with an increased risk of CVD events. Intervention in circulating tryptophan levels may be indicated to help prevent CVD. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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