Disparities in US Lung Cancer Clinical Trial Enrollment.
Background: Disparities within clinical trial enrollment are well-documented, reducing the generalizability of results. Although nearly 30 years have passed since Congress passed the NIH Revitalization Act to encourage the participation of minoritized populations in clinical trials, these patients c...
| Publicado en: | Journal of Racial & Ethnic Health Disparities Vol. 11; no. 5; pp. 3201 - 3210 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Oct2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=180269192&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 180269192 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 21973792 GQHQ jtl: Journal of Racial & Ethnic Health Disparities issn: 21973792 maglogo: N pubinfo: dt: Oct2024 vid: 11 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 180269192 171299572 180269192 180269192 10.1007/s40615-023-01776-2 180269192 ppf: 3201 ppct: 9 formats: tig: atl: Disparities in US Lung Cancer Clinical Trial Enrollment. aug: au: Kilic, Seyda Zhao, Jenny Okut, Hayrettin Jani, Chinmay T. Radwan, Amr Dudipala, Harshitha Burns, Laura Tapan, Umit affil: https://ror.org/05wvpxv85 School of Arts and Sciences, Tufts University, Medford, MA, USA sug: subj: Lung Neoplasms Therapy Research Subject Recruitment Trends Patient Selection Trends Healthcare Disparities United States Ethnic Groups Psychosocial Factors Race Factors Sex Factors Age Factors Clinical Trials Trends Human Cancer Patients Male Female Aged Consent (Research) United States Socioeconomic Disparities in Health Cancer Patients Psychosocial Factors Research Subjects Psychosocial Factors National Institutes of Health (U.S.) Clinical Trial Registry Registries, Disease T-Tests Kruskal-Wallis Test Medically Underserved Racism Sexism Comparative Studies Health Services Accessibility Descriptive Statistics Multiple Regression Data Analysis Software Aged: 65+ years Male Female ab: Background: Disparities within clinical trial enrollment are well-documented, reducing the generalizability of results. Although nearly 30 years have passed since Congress passed the NIH Revitalization Act to encourage the participation of minoritized populations in clinical trials, these patients continue to be underrepresented. This study aimed to investigate lung cancer clinical trial enrollment disparities for race/ethnicity, sex, and age. Methods: We queried the National Institutes of Health: US National Library of Medicine database of clinical trials for all US-based lung cancer clinical trials completed between 2004 and 2021 and collected data on race and ethnicity, gender, and age breakdown. This data was compared to Surveillance, Epidemiology, and End Results (SEER) database data. Independent sample t-tests and Kruskal–Wallis's approach were used to analyze the data. Results: Of 311 eligible trials with exclusive US enrollment, 136 (44%) reported race and ethnicity breakdown for the patient cohort representing 9869 patients. Hispanic, Non-Hispanic American Indian/Alaska Native, Non-Hispanic Black, and Non-Hispanic Unreported participants were underrepresented (p = 0.001, p = 0.005, p = 0.014, p = 0.002, respectively). Non-Hispanic White participants were overrepresented (p = 0.018). Disparities worsened from 2017 to 2021 for Hispanic patients (p = 0.03). No significant differences were found for sex or age. Conclusions: Disparities for clinical lung cancer trial enrollment have not shown statistically significant improvement since 2004, and representation remains unequal, especially for racial and ethnic minorities. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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