Electroconvulsive Therapy Regulates the Interhemispheric Functional Connectivity of the Dorsomedial Prefrontal Cortex in Depressive Patients: Evidence from 2 Independent Samples.
Background: The dorsomedial prefrontal cortex (dmPFC) is considered a crucial node in emotional and cognitive processes. Voxel-mirrored homotopic connectivity (VMHC) is a validated methodology for investigating interhemispheric coordination. This study aims to elucidate the effects of electroconvuls...
| Publicado en: | Actas Espanolas de Psiquiatria Vol. 52; no. 5; pp. 660 - 670 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | Artículo |
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Maria Lopez-Ibor
2024
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=lth&AN=180289135&site=ehost-live header: @attributes: shortDbName: lth uiTerm: 180289135 longDbName: MedicLatina uiTag: AN controlInfo: bkinfo: jinfo: jid: 11399287 IVZ jtl: Actas Espanolas de Psiquiatria issn: 11399287 maglogo: N pubinfo: dt: 2024 vid: 52 iid: 5 pid: 80014 pub: Maria Lopez-Ibor artinfo: ui: 180289135 10.62641/aep.v52i5.1675 ppf: 660 ppct: 10 formats: fmt: @attributes: type: P size: 3.9MB tig: atl: Electroconvulsive Therapy Regulates the Interhemispheric Functional Connectivity of the Dorsomedial Prefrontal Cortex in Depressive Patients: Evidence from 2 Independent Samples. aug: au: Loufeng Zhang Yuanyuan Guo Tongjian Bai Meidan Zu Qiang Wei Yue Wu Gongjun Ji Huaming Lv Wen Xie Kai Wang Yanghua Tian Jingyong Su affil: Department of Neurology, The First Affiliated Hospital of Anhui Medical University, 230022 Hefei, Anhui, China Department of Geriatric Psychology, The Fourth People's Hospital of Hefei, 230000 Hefei, Anhui, China Department of Medical Psychology and Sleep, The Second Affiliated Hospital of Anhui Medical University, 230601 Hefei, Anhui, China Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, 230022 Hefei, Anhui, China Hefei Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, 230022 Hefei, Anhui, China Department of Anxiety and Depression, Anhui Mental Health Center, 230000 Hefei, Anhui, China The College of Computer Science and Technology, Harbin Institute of Technology, 518055 Shenzhen, Guangdong, China su: Hamilton Depression Inventory Electroconvulsive therapy Prefrontal cortex Depressed persons Functional connectivity sug: subj: Hamilton Depression Inventory Electroconvulsive therapy Prefrontal cortex Depressed persons Functional connectivity keyword: depression dorsomedial prefrontal cortex electroconvulsive therapy voxel-mirrored homotopic connectivity ab: Background: The dorsomedial prefrontal cortex (dmPFC) is considered a crucial node in emotional and cognitive processes. Voxel-mirrored homotopic connectivity (VMHC) is a validated methodology for investigating interhemispheric coordination. This study aims to elucidate the effects of electroconvulsive therapy (ECT) on the interhemispheric connectivity of the dmPFC in patients with depression, using VMHC as a measure of bilateral neural coordination. Methods: Thirty-three patients with depression, screened at the University of Science and Technology of China (USTC), and thirty-five patients with depression, screened at Anhui Medical University (AHMU), were selected as the subjects of this study. VMHC was employed to investigate the effects of ECT on bilateral hemispheric functional connectivity. The Hamilton Depression Rating Scale (HAMD) was used to assess depressive symptoms, and the relationships between changes in HAMD scores and VMHC values were examined. Results: Following ECT, the depressive symptoms of all participants decreased (p < 0.001). The VMHC values in the dmPFC were significantly increased in both groups after ECT (p < 0.01). No significant correlation was found between the increasing VMHC values in the dmPFC and the changes in HAMD scores in depressed patients (p > 0.05). Conclusion: These results show that ECT regulates interhemispheric functional connectivity in depressed patients, and significantly increases the VMHC values in the dmPFC. Our findings may provide a useful method for optimizing the treatment of depression. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y custom: Copyright of Actas Espanolas de Psiquiatria is the property of Maria Lopez-Ibor and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. item: Actas Espanolas de Psiquiatria holder: Maria Lopez-Ibor dt: @attributes: year: 2024 holdings: @attributes: islocal: N |
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