Associations of urinary volatile organic compounds with cardiovascular disease among the general adult population.

This study was to estimate the associations of volatile organic compounds (VOCs) exposure with the prevalence of total and specific cardiovascular disease (CVD) among the general adult population. This cross-sectional study analyzed 15 urinary VOC metabolites in the general population using the 2011...

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Published in:International Journal of Environmental Health Research Vol. 34; no. 11; pp. 3876 - 3891
Main Authors: Ma, Meijuan, Zhu, Xu, Li, Feipeng, Guan, Gongchang, Hui, Rutai, Zhu, Ling, Pang, Hui, Zhang, Yong
Format: research tables/charts Journal Article
Published: Taylor & Francis Ltd Nov2024
Online Access:View this record in EBSCOhost
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      dt: Nov2024
      vid: 34
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      pub: Taylor & Francis Ltd
      place: Philadelphia, Pennsylvania
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        10.1080/09603123.2024.2331732
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        atl: Associations of urinary volatile organic compounds with cardiovascular disease among the general adult population.
      aug:
        au:
          Ma, Meijuan
          Zhu, Xu
          Li, Feipeng
          Guan, Gongchang
          Hui, Rutai
          Zhu, Ling
          Pang, Hui
          Zhang, Yong
        affil: Department of Cadre Physical Examination Center, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China
      sug:
        subj:
          Cardiovascular Diseases Epidemiology
          Cardiovascular Risk Factors Evaluation
          Organic Chemicals Urine
          Biological Markers
          Risk Assessment
          Funding Source
          Human
          Male
          Female
          Adult
          Middle Age
          Cross Sectional Studies
          Organic Chemicals Metabolism
          Metabolites
          Questionnaires
          Regression
          Angina Pectoris
          Stroke
          Environmental Exposure
          Dose-Response Relationship Evaluation
          P-Value
          Odds Ratio
          Confidence Intervals
          Descriptive Statistics
          Adult: 19-44 years
          Middle Aged: 45-64 years
          Male
          Female
      ab: This study was to estimate the associations of volatile organic compounds (VOCs) exposure with the prevalence of total and specific cardiovascular disease (CVD) among the general adult population. This cross-sectional study analyzed 15 urinary VOC metabolites in the general population using the 2011–2016 National Health and Nutrition Examination Survey (n = 5,213). The weighted study population with 47.0 years median age, was primarily female (51.2%). The prevalence of total CVD in the overall population was 7.9%. The single-exposure analyzes of AAMA, ATCA, CEMA, CYMA, DHBMA, 3HPMA, and 3MHA +4MHA were significantly associated with increased prevalence of total CVD. Qgcomp regression consistently showed that urinary VOCs-mixed exposure was positively correlated with the prevalence of total and specific CVDs (chronic heart failure, angina, and stroke), and highlighted each VOCs metabolite weights and direction. The similar results were observed for the WQS regression using mixed analysis methods. In conclusion, exposure to VOCs increases CVD prevalence and advances the identification of risk factors for CVD for environmental study.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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