The effect of mannitol on postoperative renal function in patients undergoing coronary artery bypass surgery: A double-blinded randomized controlled trial.
Introduction: Mannitol, an osmotic diuretic solution, is commonly utilized in priming cardiopulmonary bypass (CPB) and can impact kidney function. This study was conducted to investigate the impact of mannitol use during CPB on kidney function in patients undergoing coronary artery bypass surgery. M...
| Publicado en: | Journal of Cardiovascular & Thoracic Research Vol. 16; no. 3; pp. 146 - 152 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Tabriz University of Medical Sciences
Sep2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=180359750&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 180359750 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20085117 BL7R jtl: Journal of Cardiovascular & Thoracic Research issn: 20085117 maglogo: N pubinfo: dt: Sep2024 vid: 16 iid: 3 pid: 69573 pub: Tabriz University of Medical Sciences artinfo: ui: 180359750 180359750 180359750 10.34172/jcvtr.32992 180359750 ppf: 146 ppct: 6 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The effect of mannitol on postoperative renal function in patients undergoing coronary artery bypass surgery: A double-blinded randomized controlled trial. aug: au: Hemmati Maslakpak, Masumeh Bilejani, Eisa Negargar, Sohrab Khalili, Ahmadali Alinejad, Vahid Faravan, Amir affil: Maternal and Childhood Obesity Research Center, Nursing and Midwifery School, Urmia University of Medical, Urmia, Iran sug: subj: Coronary Artery Bypass Preoperative Care Mannitol Therapeutic Use Kidney Physiology Kidney Drug Effects Urinary Tract Physiology Drug Effects Postoperative Complications Prevention and Control Human Randomized Controlled Trials Double-Blind Studies Cardiac Patients Ringer's Solution Mannitol Administration and Dosage Comparative Studies Blood Urea Nitrogen Creatinine Diuresis Intensive Care Units Length of Stay Respiration, Artificial Treatment Duration Kidney Failure, Acute Prevention and Control Funding Source ab: Introduction: Mannitol, an osmotic diuretic solution, is commonly utilized in priming cardiopulmonary bypass (CPB) and can impact kidney function. This study was conducted to investigate the impact of mannitol use during CPB on kidney function in patients undergoing coronary artery bypass surgery. Methods: This randomized, double-blind clinical trial studied 90 patients undergoing coronary artery bypass surgery. In the control group (n=45), the prime solution included Ringer's lactate, and in the intervention group (n=45), the prime solution had 200 ml of mannitol 20% and Ringer's lactate. A P -value<0.05 was considered significant. The primary endpoint of this study is renal function. Results: Demographic characteristics and risk factors were not significantly different between the two groups (P >0.05). Additionally, there was no statistically significant difference between two groups in terms of CPB time, aortic cross-clamp time, length of time connected to mechanical ventilation, 30-day mortality, ICU, and hospital stay time (P >0.05). Furthermore, no statistically significant difference was observed between the two groups in serum creatinine levels (P =0.53) or BUN levels (P =0.13). The study also found no statistically significant difference in the diuresis rate between the two groups (P =0.10). Conclusion: The present study has shown that adding mannitol to the prime has no effect on kidney function, length of time connected to mechanical ventilation, length of stay in the ICU, or 30-day mortality. Therefore, it suggests that mannitol cannot be used as a preventative strategy for acute kidney injury after cardiac surgery. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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