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Assessment of Left Ventricular Functional Impairment in Patients With Chronic Kidney Disease Using Three‐Dimensional Speckle Tracking Imaging.

Background: Chronic kidney disease (CKD) is strongly linked to the incidence and mortality of cardiovascular diseases (CVDs), with left ventricular myocardial damage being the most prevalent. This study aimed to assess left ventricle (LV) dysfunction using three‐dimensional speckle tracking imaging...

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Published in:Echocardiography Vol. 41; no. 10; pp. 1 - 11
Main Authors: Gao, Xue, Xiao, Weiwei, Ji, Liqin, Li, Houyu, Zou, Anlingzi, Zhang, Xinru, Miao, Zhuomeng, Yang, Siyuan, Yu, Shaomei
Format: diagnostic images research tables/charts Journal Article
Published: Wiley-Blackwell Oct2024
Online Access:View this record in EBSCOhost
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      dt: Oct2024
      vid: 41
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      pub: Wiley-Blackwell
      place: Malden, Massachusetts
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        10.1111/echo.15928
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        atl: Assessment of Left Ventricular Functional Impairment in Patients With Chronic Kidney Disease Using Three‐Dimensional Speckle Tracking Imaging.
      aug:
        au:
          Gao, Xue
          Xiao, Weiwei
          Ji, Liqin
          Li, Houyu
          Zou, Anlingzi
          Zhang, Xinru
          Miao, Zhuomeng
          Yang, Siyuan
          Yu, Shaomei
        affil: Institution of Medical Imaging, Guizhou Medical University, Guiyang Guizhou,, China
      sug:
        subj:
          Ventricular Dysfunction, Left Radiography
          Kidney Failure, Chronic Complications
          Cardiovascular Risk Factors
          Cardiovascular Diseases Mortality
          Risk Assessment
          Imaging, Three-Dimensional Methods
          Echocardiography Methods
          Human
          Male
          Female
          Middle Age
          Glomerular Filtration Rate
          ROC Curve
          Disease Progression Risk Factors
          Univariate Statistics
          Multivariate Analysis
          Ventricular Ejection Fraction
          Creatinine Blood
          Descriptive Statistics
          One-Way Analysis of Variance
          Post Hoc Analysis
          Kruskal-Wallis Test
          Chi Square Test
          Spearman's Rank Correlation Coefficient
          Logistic Regression
          Data Analysis Software
          Odds Ratio
          Confidence Intervals
          Middle Aged: 45-64 years
          Male
          Female
      ab: Background: Chronic kidney disease (CKD) is strongly linked to the incidence and mortality of cardiovascular diseases (CVDs), with left ventricular myocardial damage being the most prevalent. This study aimed to assess left ventricle (LV) dysfunction using three‐dimensional speckle tracking imaging (3D‐STI) in CKD patients. Methods: A total of 110 CKD patients and 55 healthy volunteers underwent echocardiography. CKD patients were divided into CKD1 group and CKD2 group based on the estimated glomerular filtration rate (eGFR). Assessing cardiac function via two‐dimensional speckle tracking echocardiography (2D‐STE) and three‐dimensional speckle tracking echocardiography (3D‐STE) parameters, with strain presented in absolute terms. Collecting and comparing clinical and echocardiographic parameters from three groups, assessing 3D‐STI's value in evaluating LV functional impairment in CKD patients via correlation and receiver operating characteristic (ROC) curve analyses, and identifying risk factors for CKD progression to end‐stage renal disease (ESRD) through univariate and multivariate analyses. Results: In CKD2 group, 2D‐left ventricular ejection fraction (LVEF), 3D‐LVEF, 2D left ventricular global longitudinal strain (2D‐LVGLS), 3D‐LVGLS, and 3D‐left ventricular global circumferential peak strain (LVGCS) significantly worsen compared to the control and CKD1 groups, with statistically significant distinctions between the latter two (all p < 0.05). The absolute value of 3D‐LVGLS shows a robust correlation with N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) and serum creatinine (Scr) (r = −0.598, −0.649, both p < 0.001). ROC curve analysis indicates higher diagnostic efficacy of 3D‐LVGLS and 3D‐LVGCS for LV systolic function than 2D‐LVGLS. Univariate and multivariate analyses reveal an independent association of 3D‐LVGLS with the progression to ESRD in CKD. Conclusion: 3D‐LVGLS and 3D‐LVGCS effectively detect LV dysfunction in CKD patients. Specifically, 3D‐LVGLS demonstrates a robust correlation with NT‐proBNP and Scr and is independently linked to CKD progressing to ESRD.
      pubtype: Academic Journal
      doctype:
        diagnostic images
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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