Definition of the Post-COVID syndrome using a symptom-based Post-COVID score in a prospective, multi-center, cross-sectoral cohort of the German National Pandemic Cohort Network (NAPKON).
Purpose: The objective examination of the Post-COVID syndrome (PCS) remains difficult due to heterogeneous definitions and clinical phenotypes. The aim of the study was to verify the functionality and correlates of a recently developed PCS score. Methods: The PCS score was applied to the prospective...
| Publicado en: | Infection Vol. 52; no. 5; pp. 1813 - 1830 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Oct2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=180456864&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 180456864 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03008126 NXO jtl: Infection issn: 03008126 maglogo: N pubinfo: dt: Oct2024 vid: 52 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 180456864 176464269 180456864 180456864 10.1007/s15010-024-02226-9 180456864 ppf: 1813 ppct: 17 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Definition of the Post-COVID syndrome using a symptom-based Post-COVID score in a prospective, multi-center, cross-sectoral cohort of the German National Pandemic Cohort Network (NAPKON). aug: au: Appel, Katharina S. Nürnberger, Carolin Bahmer, Thomas Förster, Christian Polidori, Maria Cristina Kohls, Mirjam Kraus, Tanja Hettich-Damm, Nora Petersen, Julia Blaschke, Sabine Bröhl, Isabel Butzmann, Jana Dashti, Hiwa Deckert, Jürgen Dreher, Michael Fiedler, Karin Finke, Carsten Geisler, Ramsia Hanses, Frank Hopff, Sina M. affil: Center for Internal Medicine, Medical Department 2 (Hematology/Oncology and Infectious Diseases), Goethe University Frankfurt, University Hospital, Theodor-Stern-Kai 7, 60596, Frankfurt am Main, Germany sug: subj: Post-Acute COVID-19 Syndrome Symptoms Patient-Reported Outcomes Functional Assessment Phenotype Human Female Male Middle Age Prospective Studies Multicenter Studies Inpatients Outpatients Questionnaires Severity of Illness Quality of Life Sex Factors Comorbidity Comparative Studies Correlation Coefficient Descriptive Statistics Funding Source Middle Aged: 45-64 years Female Male ab: Purpose: The objective examination of the Post-COVID syndrome (PCS) remains difficult due to heterogeneous definitions and clinical phenotypes. The aim of the study was to verify the functionality and correlates of a recently developed PCS score. Methods: The PCS score was applied to the prospective, multi-center cross-sectoral cohort (in- and outpatients with SARS-CoV-2 infection) of the "National Pandemic Cohort Network (NAPKON, Germany)". Symptom assessment and patient-reported outcome measure questionnaires were analyzed at 3 and 12 months (3/12MFU) after diagnosis. Scores indicative of PCS severity were compared and correlated to demographic and clinical characteristics as well as quality of life (QoL, EQ-5D-5L). Results: Six hundred three patients (mean 54.0 years, 60.6% male, 82.0% hospitalized) were included. Among those, 35.7% (215) had no and 64.3% (388) had mild, moderate, or severe PCS. PCS severity groups differed considering sex and pre-existing respiratory diseases. 3MFU PCS worsened with clinical severity of acute infection (p =.011), and number of comorbidities (p =.004). PCS severity was associated with poor QoL at the 3MFU and 12MFU (p <.001). Conclusion: The PCS score correlated with patients' QoL and demonstrated to be instructive for clinical characterization and stratification across health care settings. Further studies should critically address the high prevalence, clinical relevance, and the role of comorbidities. Trail registration number: The cohort is registered at www.clinicaltrials.gov under NCT04768998. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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