The yeast genus Tardiomyces gen. nov. with one new species and two new combinations.
Purpose: Rare yeasts species are increasingly reported as causative agents of invasive human infection. Proper identification and antifungal therapy are essential to manage these infections. Candida blankii is one of these emerging pathogens and is known for its reduced susceptibility to multiple an...
| Publicado en: | Infection Vol. 52; no. 5; pp. 1799 - 1813 |
|---|---|
| Autores principales: | , , , , , , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Oct2024
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=180456865&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 180456865 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03008126 NXO jtl: Infection issn: 03008126 maglogo: N pubinfo: dt: Oct2024 vid: 52 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 180456865 176422828 180456865 180456865 10.1007/s15010-024-02229-6 180456865 ppf: 1799 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The yeast genus Tardiomyces gen. nov. with one new species and two new combinations. aug: au: Spruijtenburg, Bram de Souza Lima, Bruna Jacomel Favoreto Tosar, Sonia T. Granadillo Borman, Andrew M. Andersen, Cecilie Torp Nizamuddin, Summiya Ahmad, Suhail de Almeida Junior, João Nobrega Vicente, Vânia Aparecida Nosanchuk, Joshua D. Buil, Jochem B. de Hoog, Sybren Meijer, Eelco F. J. Meis, Jacques F. de Groot, Theun affil: https://ror.org/05wg1m734 Department of Medical Microbiology, Radboudumc, Nijmegen, The Netherlands sug: subj: Yeasts Genetic Variation Phenotype Phylogenetics Candida Human Drug Resistance, Microbial Culture Techniques Heterocyclic Compounds Therapeutic Use Peptides Therapeutic Use Voriconazole Therapeutic Use Descriptive Statistics Funding Source ab: Purpose: Rare yeasts species are increasingly reported as causative agents of invasive human infection. Proper identification and antifungal therapy are essential to manage these infections. Candida blankii is one of these emerging pathogens and is known for its reduced susceptibility to multiple antifungals. Methods: To obtain more insight into the characteristics of this species, 26 isolates reported as C. blankii were investigated using genetic and phenotypical approaches. Results: Among the 26 isolates, seven recovered either from blood, sputum, urine, or the oral cavity, displayed substantial genetic and some phenotypical differences compared to the other isolates, which were confirmed as C. blankii. We consider these seven strains to represent a novel species, Tardiomyces depauwii. Phylogenomics assigned C. blankii, C. digboiensis, and the novel species in a distinct branch within the order Dipodascales, for which the novel genus Tardiomyces is erected. The new combinations Tardiomyces blankii and Tardiomyces digboiensis are introduced. Differences with related, strictly environmental genera Sugiyamaella, Crinitomyces, and Diddensiella are enumerated. All three Tardiomyces species share the rare ability to grow up to 42 °C, display slower growth in nutrient-poor media, and show a reduced susceptibility to azoles and echinocandins. Characteristics of T. depauwii include high MIC values with voriconazole and a unique protein pattern. Conclusion: We propose the novel yeast species Tardiomyces depauwii and the transfer of C. blankii and C. digboiensis to the novel Tardiomyces genus. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|