The diagnostic value of salivary C-reactive protein in neonatal infections: a meta-analysis.
Purpose: C-reactive protein (CRP), as an acute phase protein, is a sensitive indicator of neonatal bacterial infection. Some recent studies have shown that there is a correlation between CRP levels in serum and saliva, and using saliva to detect CRP levels is expected to be an ideal and non-invasive...
| Publicado en: | Infection Vol. 52; no. 5; pp. 2071 - 2083 |
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| Autores principales: | , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Springer Nature
Oct2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=180456898&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 180456898 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03008126 NXO jtl: Infection issn: 03008126 maglogo: N pubinfo: dt: Oct2024 vid: 52 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 180456898 177988538 180456898 180456898 10.1007/s15010-024-02328-4 180456898 ppf: 2071 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The diagnostic value of salivary C-reactive protein in neonatal infections: a meta-analysis. aug: au: Wang, Xinning Fei, Qiang Yuan, Tianming affil: https://ror.org/025fyfd20 Department of Neonatology, Children's Hospital of Zhejiang University School of Medicine, 3333 Binsheng Road, 310000, Hangzhou, China sug: subj: Infant, Newborn, Diseases Diagnosis C-Reactive Protein Analysis Saliva Analysis Sensitivity and Specificity Human Systematic Review Meta Analysis PubMed Embase Descriptive Statistics Confidence Intervals ROC Curve Biological Markers Analysis ab: Purpose: C-reactive protein (CRP), as an acute phase protein, is a sensitive indicator of neonatal bacterial infection. Some recent studies have shown that there is a correlation between CRP levels in serum and saliva, and using saliva to detect CRP levels is expected to be an ideal and non-invasive method to predict neonatal infection. The purpose of this Meta-analysis was to evaluate the diagnostic value of salivary CRP for neonatal infection. Methods: We searched PubMed, Embase, Web of Science, and Scopus databases in October 2023 and included observational studies that examined salivary CRP in newborns with bacterial infections. Data was extracted regarding the methodology, participant characteristics, and outcome measures. Results: Nine articles were included, with a total of 696 newborns. Salivary CRP levels are significantly higher in neonates with infections compared to non-infected group (SMD = 0.58, 95%CI [0.40–0.76], P < 0.001). The accuracy for salivary CRP to predict serum CRP abnormality is high (sensitivity 86%, specificity 88%, area under the curve = 0.94). Conclusions: Our meta-analysis suggested that salivary CRP can be used as an alternative biomarker to serum CRP for detecting neonatal infection. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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