Harnessing the potential of microalgae for the production of monoclonal antibodies and other recombinant proteins.
Monoclonal antibodies (mAbs) have become indispensable tools in various fields, from research to therapeutics, diagnostics, and industries. However, their production, primarily in mammalian cell culture systems, is cost-intensive and resource-demanding. Microalgae, diverse photosynthetic microorgani...
| Publicado en: | Protoplasma Vol. 261; no. 6; pp. 1105 - 1126 |
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| Autores principales: | , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Nov2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=180498349&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 180498349 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0033183X 2CF jtl: Protoplasma issn: 0033183X maglogo: N pubinfo: dt: Nov2024 vid: 261 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 180498349 178274338 10.1007/s00709-024-01967-6 180498349 ppf: 1105 ppct: 21 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Harnessing the potential of microalgae for the production of monoclonal antibodies and other recombinant proteins. aug: au: Rajput, Balwinder Kaur Ikram, Sana Fatima Tripathi, Bhumi Nath affil: Department of Biotechnology, Indira Gandhi National Tribal University, 484887, Amarkantak, Madhya Pradesh, India sug: ab: Monoclonal antibodies (mAbs) have become indispensable tools in various fields, from research to therapeutics, diagnostics, and industries. However, their production, primarily in mammalian cell culture systems, is cost-intensive and resource-demanding. Microalgae, diverse photosynthetic microorganisms, are gaining attention as a favorable option for manufacturing mAbs and various other recombinant proteins. This review explores the potential of microalgae as a robust expression system for biomanufacturing high-value proteins. It also highlights the diversity of microalgae species suitable for recombinant protein. Nuclear and chloroplast genomes of some microalgae have been engineered to express mAbs and other valuable proteins. Codon optimization, vector construction, and other genetic engineering techniques have significantly improved recombinant protein expression in microalgae. These accomplishments demonstrate the potential of microalgae for biopharmaceutical manufacturing. Microalgal biotechnology holds promise for revolutionizing the production of mAbs and other therapeutic proteins, offering a sustainable and cost-effective solution to address critical healthcare needs. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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