In silico drug repurposing approach to predict most effective HAART for HIV drug resistance variants prevalent in the Indian HIV-positive population.
HIV epidemics still exist as a major global public health burden, especially in middle- and low-income countries. Given the lack of approved vaccines, antiretroviral therapy (ART) remains the primary approach to reduce the mortality and morbidity linked to this disease. Effective treatment for HIV-1...
| Publicado en: | AIDS Reviews Vol. 26; no. 3; pp. 93 - 102 |
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| Autores principales: | , , , |
| Formato: | Artículo |
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Publicidad Permanyer SLU
Jul-Sep2024
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=lth&AN=180522137&site=ehost-live header: @attributes: shortDbName: lth uiTerm: 180522137 longDbName: MedicLatina uiTag: AN controlInfo: bkinfo: jinfo: jid: 11396121 3PWJ jtl: AIDS Reviews issn: 11396121 maglogo: N pubinfo: dt: Jul-Sep2024 vid: 26 iid: 3 pid: 37650 pub: Publicidad Permanyer SLU artinfo: ui: 180522137 10.24875/AIDSRev.24000010 ppf: 93 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P size: 368KB tig: atl: In silico drug repurposing approach to predict most effective HAART for HIV drug resistance variants prevalent in the Indian HIV-positive population. aug: au: Kalsi, Priya Jain, Priya Goyal, Gitanjali Sharma, Himanshu affil: Department of Biochemistry, All India Institute of Medical Sciences, Bathinda, Punjab, India su: Anti-HIV agents Drug repositioning Drug resistance Low-income countries Protein stability sug: subj: Anti-HIV agents Drug repositioning Drug resistance Low-income countries Protein stability keyword: Drug resistance mutations HAART HIV drug resistance Protease Reverse transcriptase ab: HIV epidemics still exist as a major global public health burden, especially in middle- and low-income countries. Given the lack of approved vaccines, antiretroviral therapy (ART) remains the primary approach to reduce the mortality and morbidity linked to this disease. Effective treatment for HIV-1 requires the simultaneous administration of multiple drugs. However, the virus can show resistance to antiretroviral drugs, resulting in treatment failure. Therefore, this study focused on assessing the prevalence of mutations within the Indian HIV-positive population. After assessing the data, we intended to identify the most effective highly active ART (HAART) regimens for individuals with drug-resistant variants. Furthermore, our analysis revealed a spectrum of HIV mutations, with varying effects on protein stability. The significance of this analysis lies in its potential to optimize HAART selection for HIV-positive individuals by accounting for both prevalence and stability-altering mutations. By considering mutation effects on protein stability, we can modify treatment regimens, increasing the likelihood of therapy success and diminishing the risk of resistance. Moreover, this study contributes to the broader field of drug repurposing, offering insights into the rational design of antiretroviral therapies. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y custom: Copyright of AIDS Reviews is the property of Publicidad Permanyer SLU and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. item: AIDS Reviews holder: Publicidad Permanyer SLU dt: @attributes: year: 2024 holdings: @attributes: islocal: N |
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