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Maintenance Therapy Post-Hematopoietic Stem Cell Transplantation in Acute Myeloid Leukemia.

High-risk acute myeloid leukemia has been associated with a poor outcome. Hematopoietic stem cell transplantation (HSCT) represents the only curative option for eligible patients. Relapse after HSCT is a dramatic event with poor chances of survival. With the aim of reducing the rate of post-HSCT rel...

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Published in:Current Oncology Vol. 31; no. 10; pp. 6050 - 6061
Main Authors: Canichella, Martina, Molica, Matteo, Mazzone, Carla, de Fabritiis, Paolo
Format: Journal Article
Published: MDPI Oct2024
Online Access:View this record in EBSCOhost
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      dt: Oct2024
      vid: 31
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      pub: MDPI
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        10.3390/curroncol31100451
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        atl: Maintenance Therapy Post-Hematopoietic Stem Cell Transplantation in Acute Myeloid Leukemia.
      aug:
        au:
          Canichella, Martina
          Molica, Matteo
          Mazzone, Carla
          de Fabritiis, Paolo
        affil: Hematology, St. Eugenio Hospital, ASL Roma2, 00144 Rome, Italy
      sug:
      ab: High-risk acute myeloid leukemia has been associated with a poor outcome. Hematopoietic stem cell transplantation (HSCT) represents the only curative option for eligible patients. Relapse after HSCT is a dramatic event with poor chances of survival. With the aim of reducing the rate of post-HSCT relapse, maintenance treatment has been investigated in this setting. Results from clinical trials suggest an advantage in the use of a maintenance strategy; however, standardized guidelines are not yet available due to the lack of prospective clinical trials. In this review, we have reported the most important strategies adopted as post-HSCT maintenance, highlighting their efficacy, but the current research also opens questions.
      pubtype: Academic Journal
      doctype: Journal Article
      ougenre: Article
    language: English
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