A Comprehensive Review on Potential In Silico Screened Herbal Bioactive Compounds and Host Targets in the Cardiovascular Disease Therapy.
Herbal medicines (HMs) have deciphered indispensable therapeutic effects against cardiovascular disease (CVD) (the predominant cause of death worldwide). The conventional CVD therapy approaches have not been efficient and need alternative medicines. The objective of this study was a review of herbal...
| Published in: | BioMed Research International Vol. 2024; pp. 1 - 16 |
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| Main Authors: | , , , , , |
| Format: | pictorial review tables/charts Journal Article |
| Published: |
Wiley-Blackwell
10/29/2024
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=180560569&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 180560569 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 10/29/2024 vid: 2024 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 180560569 180560569 180560569 10.1155/2024/2023620 180560569 ppf: 1 ppct: 15 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: A Comprehensive Review on Potential In Silico Screened Herbal Bioactive Compounds and Host Targets in the Cardiovascular Disease Therapy. aug: au: Zarenezhad, Elham Hadi, Ali Tareq Nournia, Ensieh Rostamnia, Sadegh Ghasemian, Abdolmajid Cherstvy, Andrey affil: Noncommunicable Diseases Research Center,, Fasa University of Medical Sciences,, Fasa, Iran, fums.ac.ir sug: subj: Cardiovascular Diseases Therapy Medicine, Herbal Plants, Medicinal Therapeutic Use Plant Extracts Analysis Drug Efficacy Evaluation Molecular Structure Molecular Docking Simulation Phytochemicals Analysis Biological Products Plants, Medicinal Pharmacodynamics Organic Chemicals Pharmacodynamics Antioxidants Therapeutic Use ab: Herbal medicines (HMs) have deciphered indispensable therapeutic effects against cardiovascular disease (CVD) (the predominant cause of death worldwide). The conventional CVD therapy approaches have not been efficient and need alternative medicines. The objective of this study was a review of herbal bioactive compound efficacy for CVD therapy based on computational and in silico studies. HM bioactive compounds with potential anti‐CVD traits include campesterol, naringenin, quercetin, stigmasterol, tanshinaldehyde, Bryophyllin A, Bryophyllin B, beta‐sitosterol, punicalagin, butein, eriodyctiol, butin, luteolin, and kaempferol discovered using computational studies. Some of the bioactive compounds have exhibited therapeutic effects, as followed by in vitro (tanshinaldehyde, punicalagin, butein, eriodyctiol, and butin), in vivo (gallogen, luteolin, chebulic acid, butein, eriodyctiol, and butin), and clinical trials (quercetin, campesterol, and naringenin). The main mechanisms of action of bioactive compounds for CVD healing include cell signaling and inhibition of inflammation and oxidative stress, decrease of lipid accumulation, and regulation of metabolism and immune cells. Further experimental studies are required to verify the anti‐CVD effects of herbal bioactive compounds and their pharmacokinetic/pharmacodynamic features. pubtype: Academic Journal doctype: pictorial review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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