Platelet Reactivity with MACE in Acute Coronary Syndrome Patients Post-PCI under Dual Antiplatelet Therapy: A Meta-Analysis.
Aim/Background Acute coronary syndrome (ACS), a condition characterized by acute cardiac ischemia, is among the major causes of death from cardiovascular diseases (CVD). However, whether there is a correlation between platelet reactivity and major adverse cardiovascular events (MACE) remains debatab...
| Published in: | British Journal of Hospital Medicine (17508460) Vol. 85; no. 10; pp. 1 - 18 |
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| Main Authors: | , , , , , |
| Format: | research systematic review tables/charts Journal Article |
| Published: |
Mark Allen Holdings Limited
Oct2024
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=180563793&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 180563793 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17508460 25KN jtl: British Journal of Hospital Medicine (17508460) issn: 17508460 maglogo: N pubinfo: dt: Oct2024 vid: 85 iid: 10 pid: 11383 pub: Mark Allen Holdings Limited artinfo: ui: 180563793 180563793 180563793 10.12968/hmed.2024.0370 180563793 ppf: 1 ppct: 17 formats: tig: atl: Platelet Reactivity with MACE in Acute Coronary Syndrome Patients Post-PCI under Dual Antiplatelet Therapy: A Meta-Analysis. aug: au: Wang, Jiabing Shi, Xingliang Chen, Liuqing Li, Ting Wu, Chenttao Hu, Mingwu affil: Department of Cardiovascular Diseases, Hangzhou Xiaoshan Second People's Hospital, Hangzhou, Zhejiang, China sug: subj: Acute Coronary Syndrome Blood Percutaneous Coronary Intervention Adverse Effects Major Adverse Cardiac Events Risk Factors Biological Markers Blood Risk Assessment Dual Antiplatelet Therapy Platelet Function Tests Human Systematic Review Meta Analysis Embase PubMed Cochrane Library Descriptive Statistics Confidence Intervals ab: Aim/Background Acute coronary syndrome (ACS), a condition characterized by acute cardiac ischemia, is among the major causes of death from cardiovascular diseases (CVD). However, whether there is a correlation between platelet reactivity and major adverse cardiovascular events (MACE) remains debatable, and whether platelet function tests should be tailored for ACS patients after percutaneous coronary intervention (PCI) is still under discussion. This study aims to investigate the relationship between platelet reactivity and the occurrence of MACE in ACS patients post-PCI and to discuss the implications of these findings. Methods Clinical studies on 'PCI, ACS, dual antiplatelet therapy (DAPT), platelet reactivity, major adverse cardiovascular events (MACE)' up to 31 October 2023, were systematically collected from Embase, PubMed, and the Cochrane Library. Twelve articles meeting predefined criteria were selected. Meta-analysis was performed using Review Manager 5.4 (Cochrane, London, UK) and Stata 15.0 (StataCorp LLC, College Station, TX, USA) to compute pooled effect sizes, assess heterogeneity, explore sources of heterogeneity, and evaluate publication bias. Results Twelve articles consisting of 9297 patients were included. The meta-analysis showed that ACS patients with high platelet reactivity (HPR) who received PCI and used DAPT for 1–2 years had a greater risk of MACE (risk ratio (RR) = 1.79, 95% confidence interval (CI): 1.30–2.46) compared to those with low platelet reactivity. Moreover, greater platelet reactivity was associated independently with all-cause mortality (RR = 2.26, 95% CI: 1.63–3.12), cardiac mortality (RR = 2.87, 95% CI: 2.16–3.8), myocardial infarction (RR = 1.98, 95% CI: 1.53–2.5), in-stent restenosis (RR = 1.87, 95% CI: 1.22–2.87), as well as stroke (RR = 1.62, 95% CI: 1.02–2.57), but not with coronary revascularization events (RR = 0.99, p = 0.96, 95% CI: 0.80–1.24). On the other hand, meta-regression revealed that region (p = 0.99), type of ACS patient (p = 0.16), drug regimen (p = 0.48), testing method (p = 0.51), sampling time (p = 0.70), follow-up time (p = 0.45), and PCI protocol (p = 0.27) were not sources of heterogeneity in the study. Conclusion The meta-analysis outcomes indicate that in ACS patients receiving PCI and using dual antiplatelet therapy for 1–2 years, HPR was independently positively correlated with major adverse cardiovascular events, all-cause (or cardiac) mortality, recurrent myocardial infarction, in-stent restenosis, and stroke. This suggests that platelet reactivity testing has clinical and translational significance in predicting patients' risk of adverse cardiovascular events. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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