Feasibility of Delivering 5-Day Normobaric Hypoxia Breathing in a Hospital Setting.
BACKGROUND: Beneficial effects of breathing at FIO2 < 0.21 on disease outcomes have been reported in previous preclinical and clinical studies. However, the safety and intra-hospital feasibility of breathing hypoxic gas for 5 d have not been established. In this study, we examined the physiologic ef...
| Published in: | Respiratory Care Vol. 69; no. 11; pp. 1400 - 1409 |
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| Main Authors: | , , , , , , , , , , , , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Mary Ann Liebert, Inc.
Nov2024
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=180579727&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 180579727 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00201324 4GG jtl: Respiratory Care issn: 00201324 maglogo: N pubinfo: dt: Nov2024 vid: 69 iid: 11 pid: 1365 pub: Mary Ann Liebert, Inc. place: New Rochelle, New York artinfo: ui: 180579727 180579727 180579727 10.4187/respcare.11928 180579727 ppf: 1400 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Feasibility of Delivering 5-Day Normobaric Hypoxia Breathing in a Hospital Setting. aug: au: Berra, Lorenzo Medeiros, Kyle J. Marrazzo, Francesco Patel, Sarvagna Imber, David Rezoagli, Emanuele Yu, Binglan Sonny, Abraham Bittner, Edward A. Fisher, Daniel Chipman, Daniel Sharma, Rohit Shah, Hardik Gray, Brianna E. Harris, N. Stuart Ichinose, Fumito Mootha, Vamsi K. sug: subj: Respiration Physiology Anoxia Therapy Oxygen Hospital Units Health Care Delivery Human Massachusetts Male Female Adult Volunteer Workers Physiological Studies Oxygen Saturation Neurologic Examination Heart Rate Respiration Echocardiography Mental Status Evaluation Descriptive Statistics Erythropoietin Blood Reticulocyte Count Kruskal-Wallis Test Patient Safety Adult: 19-44 years Male Female ab: BACKGROUND: Beneficial effects of breathing at FIO2 < 0.21 on disease outcomes have been reported in previous preclinical and clinical studies. However, the safety and intra-hospital feasibility of breathing hypoxic gas for 5 d have not been established. In this study, we examined the physiologic effects of breathing a gas mixture with FIO2 as low as 0.11 in 5 healthy volunteers. METHODS: All 5 subjects completed the study, spending 5 consecutive days in a hypoxic tent, where the ambient oxygen level was lowered in a stepwise manner over 5 d, from FIO2 of 0.16 on the first day to FIO2 of 0.11 on the fifth day of the study. All the subjects returned to an environment at room air on the sixth day. The subjects' SpO2, heart rate, and breathing frequency were continuously recorded, along with daily blood sampling, neurologic evaluations, transthoracic echocardiography, and mental status assessments. RESULTS: Breathing hypoxia concentration dependently caused profound physiologic changes, including decreased SpO2 and increased heart rate. At FIO2 of 0.14, the mean SpO2 was 92%; at FIO2 of 0.13, the mean SpO2 was 93%; at FIO2 of 0.12, the mean SpO2 was 88%; at FIO2 of 0.11, the mean SpO2 was 85%; and, finally, at an FIO2 of 0.21, the mean SpO2 was 98%. These changes were accompanied by increased erythropoietin levels and reticulocyte counts in blood. All 5 subjects concluded the study with no adverse events. No subjects exhibited signs of mental status changes or pulmonary hypertension. CONCLUSIONS: Results of the current physiologic study suggests that, within a hospital setting, delivering FIO2 as low as 0.11 is feasible and safe in healthy subjects, and provides the foundation for future studies in which therapeutic effects of hypoxia breathing are tested. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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