Preliminary human health risk assessment of antibiotic exposures in human waste handling occupations.
Exposure to biosolids in human waste handling occupations is associated with a risk for illness due to microbial infections. Although several years of exposure to biosolids might be hypothesized to be a prophylaxis against infection, the risks associated with infections from antibiotic-resistant org...
| Publicado en: | Journal of Occupational & Environmental Hygiene Vol. 21; no. 10; pp. 721 - 741 |
|---|---|
| Autores principales: | , , , , , , |
| Formato: | CEU equations & formulas research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Oct2024
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=180649929&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 180649929 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15459624 V1L jtl: Journal of Occupational & Environmental Hygiene issn: 15459624 maglogo: Y pubinfo: dt: Oct2024 vid: 21 iid: 10 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 180649929 180194238 180649929 180649929 10.1080/15459624.2024.2405405 180649929 ppf: 721 ppct: 20 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Preliminary human health risk assessment of antibiotic exposures in human waste handling occupations. aug: au: Niang, Mamadou Reponen, Tiina Talaska, Glenn Ying, Jun Reichard, John F. Pecquet, Alison Maier, Andrew affil: Department of Environmental and Public Health Sciences, College of Medicine, University of Cincinnati, Cincinnati, Ohio sug: subj: Occupational Exposure Refuse Disposal Inhalation Exposure Analysis Biosolids Occupational Diseases Risk Factors Risk Assessment Antibiotics Adverse Effects Ciprofloxacin Adverse Effects Azithromycin Adverse Effects Air Pollutants, Occupational Adverse Effects Occupational Hazards Education, Continuing (Credit) Human Male Female Descriptive Statistics Environmental Pollution Occupational Health Environmental Pollutants Bacterial Infections Protozoan Infections Virus Diseases Drug Resistance, Microbial Funding Source Ciprofloxacin Analysis Azithromycin Analysis Air Pollutants, Occupational Analysis Male Female ab: Exposure to biosolids in human waste handling occupations is associated with a risk for illness due to microbial infections. Although several years of exposure to biosolids might be hypothesized to be a prophylaxis against infection, the risks associated with infections from antibiotic-resistant organisms can also be a potential concern. Therefore, this study aimed to conduct a screening level risk assessment by deriving occupational exposure limits (OELs) characterizing the risks of adverse health effects among workers in human waste handling occupations with a focus on exposure to two pharmaceuticals commonly found in biosolids: ciprofloxacin (CIP) and azithromycin (AZ). Epidemiological and exposure studies of workers exposed to biosolids were identified through searches of major scientific databases. Screening OELs (sOELs) for these antibiotics were derived using a standardized methodology. The airborne concentrations of CIP and AZ antibiotics were determined using an exposure factors approach. The health-based exposure limits (i.e., sOELs) and the acceptable daily exposure (ADE) values for both of these antibiotics were derived as 80 μg/m3 and 12 μg/kg-day, respectively. An exposure factor approach suggested that inhalation route exposures to CIP and AZ are well below the sOELs and ADE daily doses, and likely too low to cause direct adverse health effects through antibiotic inhalation. A critical review of epidemiological studies on different occupations handling biosolids showed that the workers in industries with potential biosolids exposure have experienced an increased incidence of microbial-exposure-related illness. The health effects seen in the workers have been attributed to bacterial, viral, and protozoan infections. To the extent that bacteria are the pathogen of concern, it is not clear whether these bacteria are resistant to antibiotics commonly found in biosolids. It is also unclear whether the presence of antibiotics or antibiotic-resistant bacteria increases the susceptibility of these workers. Additional studies will provide more definitive estimates of inhalation and dermal exposures to CIP and AZ and could verify the exposure estimates in this study based on the literature and common exposure factors. pubtype: Academic Journal doctype: CEU equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|