Hippocampus and olfactory impairment in Parkinson disease: a comparative exploratory combined volumetric/functional MRI study.
Introduction: Patients with Parkinson's Disease (PD) commonly experience Olfactory Dysfunction (OD). Our exploratory study examined hippocampal volumetric and resting-state functional magnetic resonance imaging (rs-fMRI) variations in a Healthy Control (HC) group versus a cognitively normal PD group...
| Publicado en: | Neuroradiology Vol. 66; no. 11; pp. 1941 - 1954 |
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| Autores principales: | , , , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Nov2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=180654032&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 180654032 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Nov2024 vid: 66 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 180654032 178670742 180654032 180654032 10.1007/s00234-024-03436-6 180654032 ppf: 1941 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Hippocampus and olfactory impairment in Parkinson disease: a comparative exploratory combined volumetric/functional MRI study. aug: au: Porcu, Michele Cocco, Luigi Marrosu, Francesco Cau, Riccardo Puig, Josep Suri, Jasjit S. Saba, Luca affil: https://ror.org/003109y17 Department of Radiology, AOU Cagliari, University of Cagliari, Cagliari, Italy sug: subj: Hippocampus Physiopathology Olfaction Disorders Physiopathology Parkinson Disease Complications Human Male Female Middle Age Aged Magnetic Resonance Imaging Methods Spearman's Rank Correlation Coefficient Scales Analysis of Covariance Mann-Whitney U Test Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Introduction: Patients with Parkinson's Disease (PD) commonly experience Olfactory Dysfunction (OD). Our exploratory study examined hippocampal volumetric and resting-state functional magnetic resonance imaging (rs-fMRI) variations in a Healthy Control (HC) group versus a cognitively normal PD group, further categorized into PD with No/Mild Hyposmia (PD-N/MH) and PD with Severe Hyposmia (PD-SH). Methods: We calculated participants' relative Total Hippocampal Volume (rTHV) and performed Spearman's partial correlations, controlled for age and gender, to examine the correlation between rTHV and olfactory performance assessed by the Odor Stick Identification Test for the Japanese (OSIT-J) score. Mann-Whitney U tests assessed rTHV differences across groups and subgroups, rejecting the null hypothesis for p < 0.05. Furthermore, a seed-based rs-fMRI analysis compared hippocampal connectivity differences using a one-way ANCOVA covariate model with controls for age and gender. Results: Spearman's partial correlations indicated a moderate positive correlation between rTHV and OSIT-J in the whole study population (ρ = 0.406; p = 0.007), PD group (ρ = 0.493; p = 0.008), and PD-N/MH subgroup (ρ = 0.617; p = 0.025). Mann-Whitney U tests demonstrated lower rTHV in PD-SH subgroup compared to both HC group (p = 0.013) and PD-N/MH subgroup (p = 0.029). Seed-to-voxel rsfMRI analysis revealed reduced hippocampal connectivity in PD-SH subjects compared to HC subjects with a single cluster of voxels. Conclusions: Although the design of the study do not allow to make firm conclusions, it is reasonable to speculate that the progressive involvement of the hippocampus in PD patients is associated with the progression of OD. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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