Choroid plexus volume changes in multiple sclerosis: insights from a systematic review and meta-analysis of magnetic resonance imaging studies.
Purpose: Multiple sclerosis (MS) is a chronic autoimmune disease characterized by the destruction of the myelin sheath within the central nervous system. The etiology of MS involves a complex interplay of genetic, environmental, and immunological factors. Recent studies indicated the potential role...
| Publicado en: | Neuroradiology Vol. 66; no. 11; pp. 1869 - 1887 |
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| Autores principales: | , , , , , |
| Formato: | pictorial research systematic review tables/charts Journal Article |
| Publicado: |
Springer Nature
Nov2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=180654033&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 180654033 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Nov2024 vid: 66 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 180654033 178850847 180654033 180654033 10.1007/s00234-024-03439-3 180654033 ppf: 1869 ppct: 18 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Choroid plexus volume changes in multiple sclerosis: insights from a systematic review and meta-analysis of magnetic resonance imaging studies. aug: au: Kolahi, Shahriar Zarei, Diana Issaiy, Mahbod Shakiba, Madjid Azizi, Narges Firouznia, Kavous affil: Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Tehran University of Medical Sciences, Tehran, Iran sug: subj: Multiple Sclerosis Diagnosis Multiple Sclerosis Physiopathology Cerebral Ventricles Pathology Cerebral Ventricles Anatomy and Histology Neuroinflammation Magnetic Resonance Imaging Professional Knowledge Human Systematic Review Meta Analysis PubMed Embase Blood-Brain Barrier Descriptive Statistics Confidence Intervals Disease Progression Cerebral Ventricles Physiopathology Checklists ab: Purpose: Multiple sclerosis (MS) is a chronic autoimmune disease characterized by the destruction of the myelin sheath within the central nervous system. The etiology of MS involves a complex interplay of genetic, environmental, and immunological factors. Recent studies indicated the potential role of the choroid plexus (CP) in the pathogenesis and progression of MS. This systematic review aims to assess existing research on the volume alterations of the CP in MS patients compared to the normal population. Methods: A comprehensive search was conducted across databases including PubMed, Embase, Scopus, and Web of Science up to June 2024. Data from the included studies were synthesized using a meta-analytical approach with a random-effects model, assessing heterogeneity with the I2 and Tau-squared indices. Results: We included 17 studies in this systematic review. The meta-analysis, which included data from eight studies reporting CP volume relative to TIV, found a statistically significant increase in CP volume in MS patients compared to healthy controls (HCs). The SMD was 0.77 (95% CI: 0.61 to 0.93), indicating a large effect size. This analysis showed no heterogeneity (I² = 0%). A separate meta-analysis was conducted using five studies that reported CP volume as normalized volume, resulting in an SMD of 0.63 (95% CI: 0.2–1.06). Conclusion: This study demonstrates an increase in CP volume among MS patients compared to HCs, implying the potential involvement of CP in MS pathogenesis and/or progression. These results show that CP might serve as a radiological indicator in the diagnosis and prognosis of MS. pubtype: Academic Journal doctype: meta analysis pictorial research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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