Effect of chia seeds or concentrated fish oil on cardiometabolic risk markers in subjects with hypertriglyceridaemia: a parallel clinical trial.
Background: The beneficial effects of n‐3 polyunsaturated fatty acids (PUFA) in reducing high blood triglyceride (TG) levels have been well demonstrated. This study aimed to investigate the effect of chia seeds on blood TG and its associated cardiometabolic factors in hypertriglyceridaemic individua...
| Published in: | Journal of Human Nutrition & Dietetics Vol. 37; no. 6; pp. 1558 - 1571 |
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| Main Authors: | , |
| Format: | research tables/charts randomized controlled trial Journal Article |
| Published: |
Wiley-Blackwell
Dec2024
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=180737319&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 180737319 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09523871 EUQ jtl: Journal of Human Nutrition & Dietetics issn: 09523871 maglogo: Y pubinfo: dt: Dec2024 vid: 37 iid: 6 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 180737319 180029515 180737319 180737319 10.1111/jhn.13369 180737319 ppf: 1558 ppct: 13 formats: tig: atl: Effect of chia seeds or concentrated fish oil on cardiometabolic risk markers in subjects with hypertriglyceridaemia: a parallel clinical trial. aug: au: Shahparvari, Mohammad Reza Nasrollahzadeh, Javad affil: Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran sug: subj: Hyperlipidemia Diet Therapy Cardiometabolic Risk Factors Biological Markers Blood Diet, Reducing Salvia Hispanica Pharmacodynamics Seeds Therapeutic Use Fish Oils Pharmacodynamics Treatment Outcomes Weight Loss Evaluation Human Randomized Controlled Trials Random Assignment Anthropometry Hypertension Diet Therapy Funding Source Triglycerides Blood Adiponectin Blood Leptin Blood Interleukins Blood ab: Background: The beneficial effects of n‐3 polyunsaturated fatty acids (PUFA) in reducing high blood triglyceride (TG) levels have been well demonstrated. This study aimed to investigate the effect of chia seeds on blood TG and its associated cardiometabolic factors in hypertriglyceridaemic individuals. Methods: This three‐group randomised controlled trial compared the effects of a low‐calorie diet (n = 22), a low‐calorie diet with chia seeds (30 g/day, n = 22) or a low‐calorie diet with concentrated fish oil (1.8 g/day of n‐3 long‐chain PUFAs, n = 22) in patients with hypertriglyceridaemia. Anthropometrics, fasting blood lipids, proprotein convertase subtilisin/kexin type 9, insulin, adiponectin, leptin and interleukin‐6 levels were measured. Results: After 8 weeks, the mean reduction in weight exhibited by the three groups was not statistically different (2.0, 2.7 and 2.8 kg, respectively, for the control, fish oil and chia seed groups). The plasma TG decreased in both the chia seed and fish oil groups in comparison to the control group (p = 0.001). However, no significant difference was observed between the chia seed and fish oil groups (change from baseline mean: 145.2 and 136.7 mg/dL for the chia seed and fish oil groups, respectively). The consumption of chia seeds was associated with a reduction in diastolic blood pressure (change from baseline mean: 8.4 mmHg) compared to the other two groups. No significant alterations were observed in the other blood biochemical factors between the three groups. Conclusions: In people with moderate hypertriglyceridaemia, a low‐calorie diet with 30 g of chia seeds compared to fish oil supplements containing 1.8 g of long‐chain PUFAs has a similar effect on reducing plasma TG levels, whereas it has a higher blood pressure–lowering effect. Key points: It is recommended that individuals with hypertriglyceridaemia implement dietary and lifestyle modifications, including weight loss and an increase in n‐3 polyunsaturated fatty acids, to reduce blood triglyceride (TG) levels.The incorporation of chia seeds into a low‐calorie diet is comparable to the administration of a moderate dose of fish oil in terms of its impact on plasma TG levels. However, it is more effective in reducing blood pressure in individuals with moderate hypertriglyceridaemia. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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