Protective Effect of High Adherence to Mediterranean Diet on the Risk of Incident Type-2 Diabetes in Subjects with MAFLD: The Di@bet.es Study.
Background/Objectives: Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) increases the risk of Type-2 Diabetes (T2DM). The Mediterranean diet (MD) has shown advantages in the management of MAFLD and preventing co-morbidities; however, its relationship with T2DM development in MAFLD has be...
| Publicado en: | Nutrients Vol. 16; no. 21; pp. 3788 - 3803 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
MDPI
Nov2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=180779819&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 180779819 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20726643 B0TT jtl: Nutrients issn: 20726643 maglogo: N pubinfo: dt: Nov2024 vid: 16 iid: 21 pid: 97109 pub: MDPI artinfo: ui: 180779819 180779819 180779819 10.3390/nu16213788 180779819 ppf: 3788 ppct: 15 formats: tig: atl: Protective Effect of High Adherence to Mediterranean Diet on the Risk of Incident Type-2 Diabetes in Subjects with MAFLD: The Di@bet.es Study. aug: au: Lago-Sampedro, Ana Oualla-Bachiri, Wasima García-Serrano, Sara Maldonado-Araque, Cristina Valdés, Sergio Doulatram-Gamgaram, Viyey Olveira, Gabriel Delgado, Elias Chaves, Felipe Javier Castaño, Luis Calle-Pascual, Alfonso Franch-Nadal, Josep Rojo-Martínez, Gemma García-Escobar, Eva affil: Centro de Investigaciónn Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain (F.J.C.) sug: subj: Mediterranean Diet Diabetes Mellitus, Type 2 Risk Factors Risk Assessment Metabolic Diseases Complications Nonalcoholic Fatty Liver Disease Complications Eating Behavior Evaluation Spanish Persons Weight Gain Human Spain Adult Female Male Secondary Analysis Prospective Studies Anthropometry Sociodemographic Factors Surveys Food Habits Glucose Tolerance Test Blood Glucose Questionnaires Chi Square Test Analysis of Variance Odds Ratio Confidence Intervals Data Analysis Software Descriptive Statistics Funding Source Adult: 19-44 years Female Male ab: Background/Objectives: Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) increases the risk of Type-2 Diabetes (T2DM). The Mediterranean diet (MD) has shown advantages in the management of MAFLD and preventing co-morbidities; however, its relationship with T2DM development in MAFLD has been less investigated. We aimed to evaluate the association of MD adherence with the risk of incident T2DM in the Spanish adult population with MAFLD and according to their weight gain at 7.5 years follow-up. Methods: A cohort of 714 participants (without weight increment: 377; with weight increment: 337) from the Di@bet.es cohort study with MAFLD and without T2DM at baseline were investigated. Anthropometric, sociodemographic, clinical data, and a survey on habits were recorded. OGTT and fasting blood biochemistry determinations were made. Baseline adherence to MD was estimated by the adapted 14-point MEDAS questionnaire and categorized as high and low adherence. Results: In total, 98 people developed T2DM at follow-up. The high adherence to MD was inversely associated with the development of T2DM in both the overall population (0.52 [0.31–0.87]) and subjects without weight gain at follow-up (0.35 [0.16–0.78]). Conclusions: Our results suggest the protective effect of high adherence to MD regarding the risk of T2DM in subjects with MAFLD, with this health benefit being more evident in men with the absence of weight gain. These results support the recommendations for MD use in these patients. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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