Can hypoxic exercise retard cellular senescence? A narrative review.
Background: Senescent cells are defined as normal cells that have undergone irreversible division arrest due to various factors. These cells have been found to play a pivotal role in aging and the development of chronic diseases. Numerous studies demonstrated that physical exercise is effective in a...
| Published in: | European Review of Aging & Physical Activity Vol. 21; no. 1; pp. 1 - 16 |
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| Main Authors: | , , |
| Format: | Article |
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BioMed Central
11/13/2024
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=180849846&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 180849846 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 18137253 3RAQ jtl: European Review of Aging & Physical Activity issn: 18137253 maglogo: N pubinfo: dt: 11/13/2024 vid: 21 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 180849846 10.1186/s11556-024-00352-9 ppf: 1 ppct: 15 formats: fmt: – @attributes: type: T – @attributes: type: P size: 1.2MB tig: atl: Can hypoxic exercise retard cellular senescence? A narrative review. aug: au: Huang, Tinghuai Tsang, Charlotte Huang, Jianwei affil: https://ror.org/0030zas98 Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, China https://ror.org/00zat6v61 Guangzhou Medical University, Guangzhou, Guangdong, China https://ror.org/00z0j0d77 The Fifth Affiliated Hospital of Guangzhou Medical University, Guangdong, China su: Older people Exercise physiology Cellular aging Sensory deprivation Exercise therapy sug: subj: Older people Exercise physiology Cellular aging Sensory deprivation Exercise therapy keyword: Altitude Hypoxia Physical exercise Senescence Altitude Hypoxia Physical exercise Senescence ab: Background: Senescent cells are defined as normal cells that have undergone irreversible division arrest due to various factors. These cells have been found to play a pivotal role in aging and the development of chronic diseases. Numerous studies demonstrated that physical exercise is effective in anti-aging and anti-chronic diseases. Furthermore, the combination of exercise and hypoxia has been shown to optimize the stimulus of oxygen deprivation and extend cellular lifespan. Objective: This narrative review offers an exhaustive analysis of existing literature studying the effect of hypoxic exercise on cellular senescence under various conditions. Methods: Four electronic databases underwent title and abstract screening to summarize the effect of hypoxic exercise on cellular senescence under various conditions. Papers were deemed eligible if they examined the effect of hypoxic exercise on cellular senescence in full-text, peer-reviewed journals and published in English. The final search was carried out on May 4, 2024. Studied were excluded if they: (a) did not involve the utilization of hypoxic exercise as a sole intervention or a contributing factor; (b) did not investigate cellular senescence; (c) lacked sufficient information regarding the study design and findings. A total of 2033 articles were obtained from four databases. However, only 11 articles were deemed to meet eligibility criteria after thoroughly examining titles, abstracts, and full-text content. Authorship, publication year, details of the experimental subject, types of exercise, training protocols, organ, tissue or cell, markers of senescent cells examined, and their responses elicited by exercise were diligently recorded. Results: This review identified 11 articles for data extraction. The sample sizes varied across a spectrum of complexity, ranging from 4 to 60 (Median=20). The studied population encompassed different healthy cohorts, which comprised sedentary males (n=6), trained males (n=2), mountain climbers (n=1), and older adults (n=2). Included studies preferred using bicycle ergometers (72.7%, n=8) as the exercise modality and 10 studies (90.9%) utilized hypoxia chambers to mimic a normobaric hypoxia environment. Four studies (36.4%) opted to utilize hypoxia chambers to mimic an altitude of 2733 and 4460 m. Additionally, 54.5% of studies (n=6) specifically investigated the effect of hypoxic exercise on lymphocytes, commonly utilizing CD28 (n=3) and CD57 (n=3) as markers of cellular senescence. Four studies (33.3%) examined the impact of hypoxic exercise on erythrocytes using CD47 as the marker for detecting senescent cells. Conclusion: These data support the notion that hypoxic exercise can retard cellular senescence of specific cells. In the future, standardization on the type of hypoxic exercise and markers of cellular senescence will be essential. Additionally, greater attention should be given to female populations and patients with different disease states. Lastly, further studies of the optimal form and dosage of exercise and the underlying cellular mechanisms are warranted. Trial registration: PROSPERO, identifier CRD42023431601. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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