Early detection of liver disease in patients with alcohol use disorder improves long-term abstinence.
Aims Excessive alcohol consumption is a major global health concern, contributing to millions of deaths annually and a significant proportion of cirrhosis cases; however, standardized protocols for early identification of alcohol-associated liver disease are lacking. In this retrospective cohort stu...
| Publicado en: | Alcohol & Alcoholism Vol. 59; no. 6; pp. 1 - 9 |
|---|---|
| Autores principales: | , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
Nov2024
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=180861090&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 180861090 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07350414 FA3 jtl: Alcohol & Alcoholism issn: 07350414 maglogo: N pubinfo: dt: Nov2024 vid: 59 iid: 6 pid: 622 pub: Oxford University Press / USA artinfo: ui: 180861090 180861090 180861090 10.1093/alcalc/agae074 180861090 ppf: 1 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Early detection of liver disease in patients with alcohol use disorder improves long-term abstinence. aug: au: Orgill, Amelia Jew, Michael H Soltani, Maryam Deioma, Ann Grant, Meghan Patton, Heather M Hsu, Cynthia L affil: Department of Medicine, VA San Diego Healthcare System , 3350 La Jolla Village Drive, San Diego, CA 92161 , United States sug: subj: Alcoholism Complications Pulmonary Fibrosis Epidemiology Liver Cirrhosis, Alcoholic Epidemiology Pulmonary Fibrosis Diagnosis Liver Cirrhosis, Alcoholic Diagnosis Alcoholism Therapy Pulmonary Fibrosis Risk Factors Liver Cirrhosis, Alcoholic Risk Factors Risk Assessment Early Diagnosis Alcohol Abstinence Outcomes (Health Care) Human Male Female Adult Middle Age Aged Veterans Retrospective Design Record Review Prospective Studies Descriptive Statistics Comparative Studies Substance Use Rehabilitation Programs Ultrasonography Chronic Disease Health Screening Collaboration Mental Health Personnel Mental Health Services Gastroenterologists Health Care Delivery, Integrated Pulmonary Fibrosis Ultrasonography Liver Cirrhosis, Alcoholic Ultrasonography California Alcohol Drinking Preventive Health Care Recovery Pulmonary Fibrosis Prognosis Liver Cirrhosis, Alcoholic Prognosis Data Analysis Software Fisher's Exact Test Kruskal-Wallis Test Post Hoc Analysis Multiple Logistic Regression Univariate Statistics Multivariate Analysis Odds Ratio Confidence Intervals Wilcoxon Signed Rank Test Alcoholism Rehabilitation Prevalence Funding Source Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Aims Excessive alcohol consumption is a major global health concern, contributing to millions of deaths annually and a significant proportion of cirrhosis cases; however, standardized protocols for early identification of alcohol-associated liver disease are lacking. In this retrospective cohort study, we aimed to understand the prevalence and risk factors associated with elevated liver stiffness measurement (LSM) in high-risk patients with alcohol use disorder (AUD) and identify variables associated with longitudinal abstinence and outcomes. Methods Veterans with severe AUD without known liver disease admitted to a 35-day residential substance use treatment program were offered liver health screening, including Fibroscan evaluation. Assessment of AUD severity and liver health outcomes were evaluated longitudinally by chart review. Results and Conclusions In a cohort of 257 veterans with severe AUD admitted to residential treatment, 185 underwent Fibroscan evaluation, and 22 were identified to have elevated LSM concerning for compensated advanced chronic liver disease. Patients with elevated LSM were more likely to remain abstinent after 1 year. About 41% of patients with LSM ≥ 10 kPa (5% of all screened patients) were confirmed to have cirrhosis on follow-up and incorporated into routine hepatology care. Screening of liver disease in high-risk populations with non-invasive imaging modalities provides an opportunity to identify patients at risk for compensated advanced chronic liver disease before decompensation. Identification of increased risk for advanced chronic liver disease may promote abstinence in patients with severe AUD. Collaboration between mental health professionals and hepatologists is critical for the integration of care for patients with AUD and liver disease. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|