Disability Moderates Dual Task Walking Performance and Neural Efficiency in Older Adults With Multiple Sclerosis.
Background: Mobility and cognitive impairment are prevalent and co-occurring in older adults with multiple sclerosis (OAMS), yet there is limited research concerning the role of disability status in the cognitive control of gait among OAMS. Objective: We investigated the levels of prefrontal cortex...
| Published in: | Neurorehabilitation & Neural Repair Vol. 38; no. 11/12; pp. 795 - 808 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Sage Publications Inc.
Dec2024
|
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=180966755&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 180966755 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15459683 IRK jtl: Neurorehabilitation & Neural Repair issn: 15459683 maglogo: Y pubinfo: dt: Dec2024 vid: 38 iid: 11/12 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 180966755 180966755 180966755 10.1177/15459683241273411 180966755 ppf: 795 ppct: 13 formats: tig: atl: Disability Moderates Dual Task Walking Performance and Neural Efficiency in Older Adults With Multiple Sclerosis. aug: au: Hernandez, Manuel E. Motl, Robert W. Foley, Frederick W. Picone, Mary Ann Izzetoglu, Meltem Lipton, Michael L. Wagshul, Mark Holtzer, Roee affil: Department of Biomedical and Translational Sciences, Carle Illinois College of Medicine, University of Illinois Urbana-Champaign, Urbana, IL, USA sug: subj: Walking Physiology Task Performance and Analysis Multiple Sclerosis Physiopathology Prefrontal Cortex Cognition Spectroscopy, Near-Infrared Methods Persons with Disabilities Hemoglobins Human Middle Age Aged Female Male Psychomotor Performance Descriptive Statistics Middle Aged: 45-64 years Aged: 65+ years Female Male ab: Background: Mobility and cognitive impairment are prevalent and co-occurring in older adults with multiple sclerosis (OAMS), yet there is limited research concerning the role of disability status in the cognitive control of gait among OAMS. Objective: We investigated the levels of prefrontal cortex (PFC) activation, using oxygenated hemoglobin (HbO2), during cognitively-demanding tasks in OAMS with lower and higher disability using functional near-infrared spectroscopy (fNIRS) to: (1) identify PFC activation differences in single task walk and cognitively-demanding tasks in OAMS with different levels of disability; and (2) evaluate if disability may moderate practice-related changes in neural efficiency in OAMS. Methods: We gathered data from OAMS with lower (n = 51, age = 65 ± 4 years) or higher disability (n = 48, age = 65 ± 5 years), using a cutoff of 3 or more, in the Patient Determined Disease Steps, for higher disability, under 3 different conditions (single-task walk, Single-Task-Alpha, and Dual-Task-Walk [DTW]) administered over 3 counterbalanced, repeated trials. Results: OAMS who had a lower disability level exhibited decreased PFC activation levels during Single-Task-Walk (STW) and larger increases in PFC activation levels, when going from STW to a cognitively-demanding task, such as a DTW, than those with higher disability. OAMS with a lower disability level exhibited greater declines in PFC activation levels with additional within session practice than those with a higher disability level. Conclusions: These findings suggest that disability moderates brain adaptability to cognitively-demanding tasks and demonstrate the potential for fNIRS-derived outcome measures to complement neurorehabilitation outcomes. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|