Hemodynamics of the Frontopolar and Dorsolateral Pre-Frontal Cortex in People with Multiple Sclerosis During Walking, Cognitive Subtraction, and Cognitive-Motor Dual-Task.
Introduction: Higher cortical activity has been observed in people with multiple sclerosis (pwMS) during walking and dual-tasking. However, further studies in overground walking and considering pre-frontal cortex (PFC) sub-areas are necessary. Objectives: To investigate PFC activity during a cogniti...
| Publicado en: | Neurorehabilitation & Neural Repair Vol. 38; no. 11/12; pp. 820 - 832 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Sage Publications Inc.
Dec2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=180966759&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 180966759 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15459683 IRK jtl: Neurorehabilitation & Neural Repair issn: 15459683 maglogo: Y pubinfo: dt: Dec2024 vid: 38 iid: 11/12 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 180966759 179591996 180966759 180966759 10.1177/15459683241279066 180966759 ppf: 820 ppct: 12 formats: tig: atl: Hemodynamics of the Frontopolar and Dorsolateral Pre-Frontal Cortex in People with Multiple Sclerosis During Walking, Cognitive Subtraction, and Cognitive-Motor Dual-Task. aug: au: Santinelli, Felipe Balistieri Veldkamp, Renee Vitório, Rodrigo Kos, Daphne Vos, Maxine Nijssen, Ruth DeLuca, John Ramari, Cintia Feys, Peter affil: REVAL Rehabilitation Research Center, University of Hasselt, Hasselt, Belgium sug: subj: Prefrontal Cortex Physiopathology Hemodynamics Multiple Sclerosis Walking Cognition Evaluation Motor Skills Task Performance and Analysis Mathematics Human Female Male Adult Middle Age Randomized Controlled Trials Random Assignment Pilot Studies Spectroscopy, Near-Infrared Hemoglobins Scales Psychological Tests Gait Neuropsychological Tests Clinical Assessment Tools Questionnaires Patient-Reported Outcomes Repeated Measures Two-Way Analysis of Variance Comparative Studies Correlation Coefficient Data Analysis Software T-Tests Wilcoxon Rank Sum Test Descriptive Statistics Funding Source Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Introduction: Higher cortical activity has been observed in people with multiple sclerosis (pwMS) during walking and dual-tasking. However, further studies in overground walking and considering pre-frontal cortex (PFC) sub-areas are necessary. Objectives: To investigate PFC activity during a cognitive-motor dual-task (DT) and its single component tasks, in combination with behavioral outcomes in pwMS. Methods: Fifteen pwMS (EDSS 3.5 [2-5.5], 42 ± 11 years) and 16 healthy controls (HC, 45.2 ± 13.2 years) performed 3 conditions: single motor-walking (SWT), single cognitive – subtracting sevens (SCT), and a DT. Meters walked and the number of correct answers were obtained from which, respectively, the motor (mDTC) and cognitive (cDTC) DT costs were calculated. A functional Near-Infrared Spectroscopy covering the frontopolar and dorsolateral PFC (DLPFC) areas was used to concentration of relative oxyhemoglobin (ΔHbO2) and deoxyhemoglobin (ΔHHb) in the PFC. A repeated 2-way ANOVA (group × conditions) was used to compare ΔHbO2/ΔHHb and behavioral outcomes. Results: PwMS walked shorter distances (P <.002) and answered fewer correct numbers (P <.03) than HC in all conditions, while cDTC and mDTC were similar between groups. PwMS presented higher ΔHbO2 in the frontopolar area than HC in the SWT (P <.001). HC increased ΔHbO2 in frontopolar during the SCT (P <.029) and DT (P <.037) compared with the SWT. Conclusion: Higher frontopolar activity in pwMS compared to HC in the SWT suggests reduced gait automaticity. Furthermore, it seems that only HC increased neural activity in the frontopolar in the SCT and DT, which might suggest a limit of cognitive resources to respond to DT in pwMS. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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