Concepts of Actionability in Precision Oncology.

"Actionability" is a key concept in precision oncology. Its precise definition, however, remains contested. This article undertakes a philosophical analysis of "actionability" to aid in conceptual clarification. We map distinct concepts of actionability, arguing that each is best understood as a con...

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Publicado en:Philosophy of Science Vol. 91; no. 5; pp. 1349 - 1361
Autores principales: Chin-Yee, Benjamin, Plutynski, Anya
Formato: Artículo
Publicado: Cambridge University Press Dec2024
Materias:
Acceso en línea:Ver este registro en EBSCOhost
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        atl: Concepts of Actionability in Precision Oncology.
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          Chin-Yee, Benjamin
          Plutynski, Anya
        affil:
          Department of History and Philosophy of Science, University of Cambridge, Cambridge, UK
          Division of Hematology, Department of Medicine, Schulich School of Medicine and Dentistry, London, Ontario, Canada
          Department of Philosophy, Washington University in St. Louis, St. Louis, Missouri, USA
      su:
        Concept mapping
        Philosophers
        Pluralism
        Medical personnel
        Oncology
      sug:
        subj:
          Concept mapping
          Philosophers
          Pluralism
          Medical personnel
          Oncology
      ab: "Actionability" is a key concept in precision oncology. Its precise definition, however, remains contested. This article undertakes a philosophical analysis of "actionability" to aid in conceptual clarification. We map distinct concepts of actionability, arguing that each is best understood as a contextually objective category articulated to mitigate risk of "conceptual slippage." We defend "interactive pluralism," acknowledging the need for distinct concepts but also for conceptual interaction in practice. This article thus offers insights for both practitioners and philosophers, clarifying approaches to actionability for scientists and clinicians and serving as a case study to test competing views on scientific pluralism.
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