A pro‐reparative bioelectronic device for controlled delivery of ions and biomolecules.
Wound healing is a complex physiological process that requires precise control and modulation of many parameters. Therapeutic ion and biomolecule delivery has the capability to regulate the wound healing process beneficially. However, achieving controlled delivery through a compact device with the a...
| Publicado en: | Wound Repair & Regeneration Vol. 32; no. 5; pp. 709 - 720 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Sep2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=180986446&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 180986446 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10671927 DPV jtl: Wound Repair & Regeneration issn: 10671927 maglogo: Y pubinfo: dt: Sep2024 vid: 32 iid: 5 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 180986446 180986446 180986446 10.1111/wrr.13191 180986446 ppf: 709 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: A pro‐reparative bioelectronic device for controlled delivery of ions and biomolecules. aug: au: Asefifeyzabadi, Narges Nguyen, Tiffany Li, Houpu Zhu, Kan Yang, Hsin‐ya Baniya, Prabhat Medina Lopez, Andrea Gallegos, Anthony Hsieh, Hao‐Chieh Dechiraju, Harika Hernandez, Cristian Schorger, Kaelan Recendez, Cynthia Tebyani, Maryam Selberg, John Luo, Le Muzzy, Elana Hsieh, Cathleen Barbee, Alexie Orozco, Jonathan affil: Department of Electrical and Computer Engineering, University of California Santa Cruz, Santa Cruz California,, USA sug: subj: Electric Stimulation Equipment and Supplies Drug Delivery Systems Methods Ions Administration and Dosage Biological Products Administration and Dosage Wound Healing Animal Studies Funding Source Mice Zolmitriptan In Vivo Studies Macrophages Ion Pumps Models, Biological ab: Wound healing is a complex physiological process that requires precise control and modulation of many parameters. Therapeutic ion and biomolecule delivery has the capability to regulate the wound healing process beneficially. However, achieving controlled delivery through a compact device with the ability to deliver multiple therapeutic species can be a challenge. Bioelectronic devices have emerged as a promising approach for therapeutic delivery. Here, we present a pro‐reparative bioelectronic device designed to deliver ions and biomolecules for wound healing applications. The device incorporates ion pumps for the targeted delivery of H+ and zolmitriptan to the wound site. In vivo studies using a mouse model further validated the device's potential for modulating the wound environment via H+ delivery that decreased M1/M2 macrophage ratios. Overall, this bioelectronic ion pump demonstrates potential for accelerating wound healing via targeted and controlled delivery of therapeutic agents to wounds. Continued optimization and development of this device could not only lead to significant advancements in tissue repair and wound healing strategies but also reveal new physiological information about the dynamic wound environment. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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