Placenta‐derived mesenchymal stem cells promote diabetic wound healing via exosomal protein interaction networks.
There is a lack of effective treatment options for diabetic refractory wounds, which presents a critical clinical issue that needs to be addressed urgently. Our research has demonstrated that human placenta‐derived mesenchymal stem cells (plaMSCs) facilitate the migration and proliferation of HaCat...
| Publicado en: | Wound Repair & Regeneration Vol. 32; no. 5; pp. 638 - 652 |
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| Autores principales: | , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Sep2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=180986448&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 180986448 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10671927 DPV jtl: Wound Repair & Regeneration issn: 10671927 maglogo: Y pubinfo: dt: Sep2024 vid: 32 iid: 5 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 180986448 178476634 180986448 180986448 10.1111/wrr.13199 180986448 ppf: 638 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Placenta‐derived mesenchymal stem cells promote diabetic wound healing via exosomal protein interaction networks. aug: au: Peng, Cheng Xu, Hongbo Zhuang, Quan Liu, Jinya Ding, Yinhe Tang, Qiyu Wang, Zheng Yao, Kai affil: Department of Burns and Plastic Surgery, The Third Xiangya Hospital of Central South University, Changsha, China sug: subj: Diabetes Mellitus Complications Diabetic Foot Therapy Wound Care Methods Placenta Mesenchymal Stem Cells Transplantation Wound Healing Evaluation Exosomes Proteins Signal Transduction Human Funding Source Cell Movement Keratinocytes Cell Line Proteomics Gene Expression Bioinformatics Extracellular Matrix Cell Physiology Cell Proliferation Neovascularization, Physiologic ab: There is a lack of effective treatment options for diabetic refractory wounds, which presents a critical clinical issue that needs to be addressed urgently. Our research has demonstrated that human placenta‐derived mesenchymal stem cells (plaMSCs) facilitate the migration and proliferation of HaCat cells, thereby enhancing diabetic wound healing primarily via the exosomes derived from plaMSCs (plaMSCs‐Ex). Using label‐free proteomics, plaMSCs and their exosomes were analysed for proteome taxonomic content in order to explore the underlying effective components mechanism of plaMSCs‐Ex in diabetic wound healing. Differentially expressed proteins enriched in plaMSCs‐Ex were identified and underwent bioinformatics analysis including GO annotation, KEGG pathway enrichment, gene set enrichment analysis (GSEA) and protein–protein interaction analysis (PPI). Results showed that the proteins enriched in plaMSCs‐Ex are significantly involved in extracellular matrix organisation, epithelium morphogenesis, cell growth, adhesion, proliferation and angiogenesis. PPI analysis filtered 2 wound healing‐related clusters characterised by hub proteins such as POSTN, FN1, SPARC, TIMP1, SERPINE1, LRP1 and multiple collagens. In brief, the exosomal proteins derived from plaMSCs reveal diverse functions of regeneration and tissue remodelling based on proteomics analysis and potentially play a role in diabetic wound healing. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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