Biodegradation Study of Biomaterials Composed of Acrylated Epoxidized Soybean Oil: An In Vitro Study.

In the field of regenerative medicine, acrylated epoxidized vegetable oils are emerging as a promising avenue of exploration. The aim of this study is to evaluate the degradability of two formulations of acrylated epoxidized soybean oil (AESO): pure AESO and AESO diluted with soybean oil (SO) for po...

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Publicado en:BioMed Research International Vol. 2024; pp. 1 - 11
Autores principales: Sibilia, Diego, Amendolea, Martina, Sangiovanni, Roberta, Bragaglia, Mario, Nicoletti, Fabrizio, Filetici, Pierfrancesco, D'Addona, Antonio, Nanni, Francesca, Dassatti, Leonardo, Nocca, Giuseppina, Silva, Edilene O.
Formato: pictorial research tables/charts Journal Article
Publicado: Wiley-Blackwell 11/22/2024
Acceso en línea:Ver este registro en EBSCOhost
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      dt: 11/22/2024
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      pub: Wiley-Blackwell
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        10.1155/bmri/7100988
        181057635
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        atl: Biodegradation Study of Biomaterials Composed of Acrylated Epoxidized Soybean Oil: An In Vitro Study.
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        au:
          Sibilia, Diego
          Amendolea, Martina
          Sangiovanni, Roberta
          Bragaglia, Mario
          Nicoletti, Fabrizio
          Filetici, Pierfrancesco
          D'Addona, Antonio
          Nanni, Francesca
          Dassatti, Leonardo
          Nocca, Giuseppina
          Silva, Edilene O.
        affil: Dipartimento di Scienze della Vita e Sanità Pubblica,, Università Cattolica del Sacro Cuore,, Largo F. Vito 1, 00168,, Rome, Italy, unicatt.it
      sug:
        subj:
          Tissue Engineering Methods
          Biodegradable Materials
          Soybean Oil
          Acrylates
          Ethers
          Human
          In Vitro Studies
          Funding Source
          Bone Regeneration
          Biochemical Phenomena
          Tissue Scaffolds
          Oxidative Stress
          Extracellular Matrix
          Hydrolases Metabolism
          Polymers Metabolism
      ab: In the field of regenerative medicine, acrylated epoxidized vegetable oils are emerging as a promising avenue of exploration. The aim of this study is to evaluate the degradability of two formulations of acrylated epoxidized soybean oil (AESO): pure AESO and AESO diluted with soybean oil (SO) for potential bioprintability applications. The comprehensive investigation of these two polymeric formulations included optimization of polymerization conditions, confirmation of cytocompatibility, and, most importantly, the study of their degradability. The results reveal that AESO, used as a biomaterial for biomedical applications, undergoes a distinctive degradation process, combining both enzymatic and oxidative degradation (AESO/SO samples lose 29.45% of their weight after 60 days). This phenomenon is the result of a complex interplay of factors, including the chemical composition and physical characteristics of the polymer, the unique tissue environment in which it is implanted, and the duration of implantation.
      pubtype: Academic Journal
      doctype:
        pictorial
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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