Polyphenol hydroxytyrosol present olive oil improves skin wound healing of diabetic mice.
The imbalance in oxidant production and chronic inflammation are the main mechanisms that lead to the detrimental effects of diabetes on skin wound healing. Thus, administration of antioxidants could improve diabetic wound healing. This study aimed to understand the effects of extra virgin olive oil...
| Published in: | Wound Repair & Regeneration Vol. 32; no. 6; pp. 904 - 916 |
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| Main Authors: | , , , |
| Format: | pictorial research tables/charts Journal Article |
| Published: |
Wiley-Blackwell
Nov2024
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=181057813&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 181057813 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10671927 DPV jtl: Wound Repair & Regeneration issn: 10671927 maglogo: Y pubinfo: dt: Nov2024 vid: 32 iid: 6 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 181057813 179389407 181057813 181057813 10.1111/wrr.13217 181057813 ppf: 904 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Polyphenol hydroxytyrosol present olive oil improves skin wound healing of diabetic mice. aug: au: Duarte, Matheus Silva Fuhro, Victor Müller de Souza Nogueira, Jeane Romana‐Souza, Bruna affil: Department of Histology and Embryology, State University of Rio de Janeiro, Rio de Janeiro, Brazil sug: subj: Skin Injuries Wound Healing Diabetes Mellitus Olive Oil Pharmacodynamics Polyphenols Pharmacodynamics Animal Studies Mice In Vitro Studies Fibroblasts Macrophages Collagen Drug Effects Neutrophils Drug Effects Tumor Necrosis Factor Drug Effects Lipid Peroxidation Drug Effects NF-E2-Related Factor 2 Drug Effects Interleukins Phenotype Dietary Supplementation Funding Source ab: The imbalance in oxidant production and chronic inflammation are the main mechanisms that lead to the detrimental effects of diabetes on skin wound healing. Thus, administration of antioxidants could improve diabetic wound healing. This study aimed to understand the effects of extra virgin olive oil (EVOO) or hydroxytyrosol (HT) in skin wound healing under diabetic conditions. Skin wounds in streptozotocin‐induced diabetic mice were topically treated with HT. Some diabetic animals were fed with a diet rich in EVOO. Wounds were harvested 7 days later. In in vitro assays, fibroblasts and macrophages were treated with high levels of glucose and HT. The EVOO or HT promoted wound closure and collagen deposition in diabetic mouse wounds. The EVOO or HT reduced the number of infiltrated neutrophils, tumour necrosis factor‐α, lipid peroxidation, and nuclear factor erythroid 2‐related factor 2 in diabetic mouse wounds. The EVOO or HT also increased the number of macrophages with anti‐inflammatory phenotype and interleukin‐10 in diabetic mouse wounds. In the in vitro assays, HT promoted the fibroblast migration, collagen gel contraction, and switched macrophages to an anti‐inflammatory phenotype under high glucose conditions. In conclusion, the diet supplementation with EVOO or topical application of HT promotes skin wound healing under diabetic conditions and can be a possible therapeutic tool for the treatment of those lesions. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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