A systematic review of symptoms experienced by children and young people with kidney failure.
Background: Kidney failure at any age has a significant impact on quality of life (QoL) but the overall symptom burden for children and young people (CYP) is poorly described. Kidney failure has no cure and whilst transplantation is the preferred management option, it is not always possible, with pa...
| Publicado en: | Pediatric Nephrology Vol. 40; no. 1; pp. 53 - 69 |
|---|---|
| Autores principales: | , , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Springer Nature
Jan2025
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=181065969&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 181065969 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0931041X EF1 jtl: Pediatric Nephrology issn: 0931041X maglogo: N pubinfo: dt: Jan2025 vid: 40 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 181065969 178759873 181065969 181065969 10.1007/s00467-024-06465-8 181065969 ppf: 53 ppct: 16 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: A systematic review of symptoms experienced by children and young people with kidney failure. aug: au: Jacob, Zoe Plumb, Lucy Oni, Louise Mitra, Siona Reynolds, Ben affil: Dept. of Medical Paediatrics, Royal Aberdeen Children's Hospital, NHS Grampian, Aberdeen, UK sug: subj: Renal Insufficiency Complications Symptom Burden Terminally Ill Patients Human Systematic Review Child Kidney Failure, Chronic Complications Sleep Disorders Risk Factors Mental Disorders Risk Factors Gastrointestinal Diseases Risk Factors Skin Diseases Risk Factors Otorhinolaryngologic Diseases Risk Factors Nervous System Diseases Risk Factors Eye Diseases Risk Factors Restless Legs Risk Factors Disorders of Excessive Somnolence Risk Factors Depression Risk Factors Anxiety Risk Factors Nausea and Vomiting Risk Factors Abdominal Pain Risk Factors Eating Disorders Risk Factors Anorexia Risk Factors Headache Risk Factors Pruritus Risk Factors Child: 6-12 years ab: Background: Kidney failure at any age has a significant impact on quality of life (QoL) but the overall symptom burden for children and young people (CYP) is poorly described. Kidney failure has no cure and whilst transplantation is the preferred management option, it is not always possible, with patients requiring supportive care at the end of their lives. Aim: To use the literature to understand the symptom burden for CYP with kidney failure who are approaching end-of-life. Methods: Using three databases, a systematic literature review was performed to identify eligible studies to extract data on symptoms experienced in CYP aged < 21 years with kidney failure. Data extraction was completed by two authors using a pre-designed proforma. Study quality assessment was undertaken using the BMJ AXIS tool. Results: A total of 20,003 titles were screened to yielding 35 eligible studies including 2,862 CYP with chronic kidney disease (CKD), of whom 1,624 (57%) had CKD stage 5. The studies included a median of 30 (range 7–241) patients. Symptoms were subcategorised into eight groups: sleep, mental health, gastrointestinal, dermatology, ear, nose and throat (ENT), neurology, multiple symptoms, and ophthalmology. The prevalences of the most commonly reported symptoms were: restless leg syndrome 16.7–45%, sleep disordered breathing 20–46%, hypersomnia 14.3–60%, depression 12.5–67%, anxiety 5.3–34%, overall gastrointestinal symptoms 43–82.6%, nausea and vomiting 15.8–68.4%, abdominal pain 10.5–67.4%, altered appetite or anorexia 19–90%, xerosis 53.5–100%, pruritis 18.6–69%, headache 24–76.2% and ophthalmological symptoms 26%. Within each subgroup, the symptom definitions used were heterogeneous, the methods of assessment were varied and some symptoms, such as pain and constipation, were poorly represented. Conclusions: There is a marked lack of evidence relating to the symptom burden for CYP with CKD. This study highlights the high symptom prevalence, particularly in relation to sleep, mental health, headache, dermatological and gastrointestinal symptoms. There is a need for consensus recommendations on the evaluation and management of symptoms for CYP with CKD approaching end-of-life. PROSPERO ID: CRD42022346120. pubtype: Academic Journal doctype: research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|